The Pathophysiological Role of Adrenergic Antibodies in Postural Tachycardia Syndrome (Aims #1&2)
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY
Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:
• Patients who have been previously diagnosed with POTS
• Control subjects (patients not diagnosed with POTS)
• Age between 18 - 60 years
• Males and Females (Give that \>80% of POTS patients are female, we will attempt to enroll a similar percentage of female control subjects)
• Able and willing to provide consent
Locations
Other Locations
Canada
University of Calgary
RECRUITING
Calgary
Contact Information
Primary
Satish R Raj, MD, MSCI
autonomic.research@ucalgary.ca
403-210-6152
Backup
Robert S Sheldon, MD, PhD
autonomic.research@ucalgary.ca
403-220-8191
Time Frame
Start Date: 2016-01
Estimated Completion Date: 2027-12
Participants
Target number of participants: 125
Treatments
Postural Tachycardia Syndrome (POTS)
Patients with postural tachycardia syndrome; patients will receive both IV phenylephrine and IV isoproterenol
Healthy (control) Subjects
Healthy volunteers that are gender and age-matched (by groups) to the POTS patients; healthy subjects will receive both IV phenylephrine and IV isoproterenol
Related Therapeutic Areas
Sponsors
Leads: University of Calgary