Measures of Respiratory Health
The Lung Clearance Index, measured by multiple breath washout, is a measure of lung function that is considered a research tool in Canada as the device used to measure it is not approved by Health Canada. The study will assess lung function in patients undergoing routine lung function testing for clinical indications (Cystic Fibrosis and Other Respiratory Diseases). In addition, healthy controls of different ages will be asked to perform this lung function test to gain reference data that can be used to interpret LCI in patients with lung disease.
• 2.5 - 18 years of age at enrolment
• Diagnosis of CF as evidenced by one or more clinical feature consistent with the CF phenotype or positive CF newborn screen AND one or more of the following criteria:
‣ A documented sweat chloride ≥ 60 mEq/L by quantitative pilocarpine iontophoresis (QPIT)
⁃ A documented genotype with two disease-causing mutations in the CFTR gene
• Informed consent by participant, parent, or legal guardian
• Ability to perform technically acceptable MBW measurements
• MD diagnosed lung disease and/or attending the Pulmonary Function Laboratory
• 2.5 - 18 years of age at enrollment
• Informed consent by participant, parent, or legal guardian
• Ability to perform technically acceptable MBW measurements
• 2.5 - 30 years of age at enrollment
• Informed consent by participant, parent, or legal guardian
• Ability to perform technically acceptable MBW measurements