AntiPlatelet theraPy stratEgy followiNg Left Atrial appenDAGe closurE
The APPENDAGE study is a phase 4 multicentre randomized opened clinical trial comparing 2 different antithrombotic strategies following left atrial appendage closure (LAAC) in patients with non valvular atrial fibrillation (AF). The primary objective of the study is to evaluate the efficacy of Aspirin versus Aspirin + Clopidogrel after LAAC by comparing the occurrence of ischemic lesions on cerebrovascular magnetic resonance imaging (MRI) studies.
• Male or female patients with LAAC indication according to Commission nationale d'évaluation des dispositifs médicaux et des technologies de santé (CNEDiMTS) (National Commission for the Evaluation of Medical Devices and Health Technologies) guidelines
• Age ≥ 18 years
• Written informed consent provided by the patient
• Heart team approval: multidisciplinary team including interventional cardiologists, neurologists and other physicians discussing the definitive contraindication for anticoagulation
• Registration under social security system