Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
This study will determine whether early, comprehensive, rhythm control therapy prevents adverse cardiovascular outcome in patients with acute ischemic stroke and atrial fibrillation compared to usual care.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Acute ischemic stroke in the previous four weeks, diagnosed by imaging (CT or MRI) or clinical diagnosis
• Possibility to start the trial treatment within 4 weeks after stroke, and as soon as clinically justifiable
• AF first detected ≤1 year prior to randomization
• Informed consent
Locations
Other Locations
Germany
University Medical Center Hamburg-Eppendorf
RECRUITING
Hamburg
Contact Information
Primary
Märit Jensen, MD
m.jensen@uke.de
+4940741053770
Backup
Götz Thomalla, MD
thomalla@uke.de
+4940741050137
Time Frame
Start Date: 2025-11-06
Estimated Completion Date: 2031-09
Participants
Target number of participants: 1746
Treatments
Experimental: Early rhythm control therapy
Patients with acute ischemic stroke and AF will receive either catheter ablation (mainly pulmonary vein isolation), or adequate antiarrhythmic drug therapy at an early time point. The initial therapy will be selected by the local investigator. In case of continuation or recurrence of AF, both modalities may be combined.
Active_comparator: Usual care
Patients with acute ischemic stroke and AF will receive usual care following the current ESC guidelines for AF treatment.
Related Therapeutic Areas
Sponsors
Collaborators: UMC Utrecht, University Heart & Vascular Center Hamburg, Department of Cardiology, Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Stroke Alliance for Europe (SAFE), CTC-NORTH, Melbourne Heart Centre, Royal Melbourne Hospital, Hotchkiss Brain Institute, University of Calgary, Kompetenznetz Vorhofflimmern e.V. (AFNET), Department of Neurology, Royal Melbourne Hospital, Edinburgh Clinical Trials Unit, Cerebrovascular Research Group, Centre for Clinical Brain Sciences, University of Edinburgh, Department of Cardiovascular Sciences, University of Leicester British Heart Foundation Cardiovascular Research Centre
Leads: Universitätsklinikum Hamburg-Eppendorf