Study of Behavioral Dysfunctions and Related Neuronal Correlates in Patients With Dystonia

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Dystonias represent hyperkinetic movement disorders characterized by protracted muscle contractions, such as to cause torsional movements and anomalous postures in different parts of the body. Although they occur more often in a focal form (blepharospasm, oromandibular dystonia, cervical dystonia, laryngeal dystonia, attitudinal cramps of the limbs) than segmental (involvement of several contiguous muscle groups, e.g. facial muscles and neck muscles), they are nevertheless capable of significantly influencing the quality of life, with consequent social and health costs. Although described as a predominantly motor disorder, the presence of non-motor symptoms in dystonias associated with alteration of the fronto-striatal circuits is increasingly recognized. Neuroimaging studies have highlighted that the striatum and, more specifically, striatal dopamine, is involved in high cognitive processes such as attention, reward-based learning and decision making. Clinical conditions associated with cortico-striatal circuit dysfunction and abnormal meso-striatal or meso-cortical dopamine transmission also appear to influence temporal estimation, delay discounting, showing an impulsive preference for immediate rewards over delayed gratification. Based on these premises, the present project aims to evaluate the cognitive and affective aspects of dystonias, in line with neuroimaging research documenting structural and functional dysfunctions in the respective brain regions.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:

• \> 18 years old;

• Informed consent;

• Montreal cognitive assessment \> 21;

Locations
Other Locations
Italy
IRCCS Centro Neurolesi Bonino Pulejo
RECRUITING
Messina
Time Frame
Start Date: 2024-01-10
Estimated Completion Date: 2025-10-10
Participants
Target number of participants: 102
Treatments
Experimental: experimental group
patients with dystonia were submitted to a neuropsychological evaluation
Experimental: control group
healthy patients were submitted to a neuropsychological evaluation
Sponsors
Leads: IRCCS Centro Neurolesi Bonino Pulejo

This content was sourced from clinicaltrials.gov