Status of Chronic Pain in Patients With Hemophilia.

Status: Recruiting
Location: See all (10) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Hemophilia (A and B) are X-linked hereditary bleeding disorders whose severity depends on the level of coagulation factor (FVIII or FIX respectively). Bleeding is mainly from joints (hemarthrosis) and muscles (hematoma). Nowadays, treatment is based on preventive or curative intravenous infusion of coagulation factor concentrates. Despite these treatments, there is joint deterioration that can be responsible for hemophilic arthropathy and chronic pain. This pain may be related to excess nociception during acute bleeding, but it may also be neuropathic. There are only a few studies that have looked at pain in hemophilia, but it is accepted that the vast majority of patients (especially those with severe forms) suffer from chronic pain. Because patients have become accustomed to this pain and physicians are still not very aware of how to assess it, this pain is not treated effectively. In order to better manage pain in hemophilia, it is therefore necessary to characterize their pain and to know the nociceptive or neuropathic component. The aim of our study is therefore to study the prevalence, the nociceptive or neuropathic profile, the chronic aspect of pain and the main locations of pain in hemophilia. In addition to raising the awareness of physicians in the centers about pain management using specific questionnaires, this survey will help to better define chronic pain in hemophilia of all severities.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient with haemophilia of any severity,

• Carrier female with low levels haemophilia (\< 40%),

• ≥ 18 years of age and capable of giving informed consent to participate in research.

Locations
Other Locations
France
CHU de Bordeaux
RECRUITING
Bordeaux
Centre Hospitalier Universitaire de Caen Normandie
NOT_YET_RECRUITING
Caen
CH Métropole Savoie
RECRUITING
Chambéry
CHU de Clermont-Ferrand
RECRUITING
Clermont-ferrand
CHU de Grenoble
RECRUITING
Grenoble
CHU de LILLE
NOT_YET_RECRUITING
Lille
Hospices Civils de Lyon
RECRUITING
Lyon
Centre Hospitalier Universitaire de Nantes
RECRUITING
Nantes
CHU de Saint-Etienne
RECRUITING
Saint-etienne
CHU de TOULOUSE
RECRUITING
Toulouse
Contact Information
Primary
Lise LACLAUTRE
promo_interne_drci@chu-clermontferrand.fr
+33473754963
Time Frame
Start Date: 2022-02-28
Estimated Completion Date: 2026-08
Participants
Target number of participants: 350
Treatments
Patients with hemophilia
all adult patients follow-upin Hospital for hemophilia
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Clermont-Ferrand

This content was sourced from clinicaltrials.gov