• Patients with history of a WHO Grade II-IV glioma with radiographic evidence of recurrent or progressive tumor

‣ Patient must have received prior radiation therapy for initial treatment of glioma

⁃ Patients with any number of recurrences are allowed as long as the patient has not undergone re-irradiation

• Brain MRI with contrast demonstrates an enhancing tumor ≤ 6 cm in largest diameter within 60 days prior to registration

• History and physical including neurological exam within 30 days prior to registration

• Karnofsky performance status ≥ 60% within 30 days prior to registration

• Age ≥ 22 years old

• Minimum interval since completion of prior radiation treatment is 8 weeks

‣ Patients will only receive re-irradiation if pathology from LITT is consistent with recurrent tumor

• Patients must have signed an approved informed consent

• Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.

• Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.