Chronic Lymphocytic Leukemia (CLL) Clinical Trials

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An Interventional Study of Dietary Effects on Immune Function, Metabolism and Disease Activity in Early-Stage Chronic Lymphocytic Leukemia

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to investigate whether a short-term (4-week) whole-food, plant-based (WFPB) diet has an effect on metabolism, immune function, and disease activity in early-stage chronic lymphocytic leukemia (CLL). The main questions the study aims to answer are: * Does a WFPB diet influence disease progression? * How do CLL cells and other immune cell types respond to a WFPB diet in terms of metabolism and signaling? Researchers will examine whether a WFPB diet can affect absolute lymphocyte counts in participants' blood and what metabolic or functional changes occur within the CLL cells. Participants will: * Switch to a WFPB diet for 4 weeks following an introductory session with a certified dietary instructor. * Visit the clinic before starting the diet and again after 14 and 28 days for blood draws and to provide stool samples. * Keep a diary of all foods and drinks consumed during the week prior to and throughout the study period.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Confirmed CLL diagnosis

• No previous treatments (watch and wait)

• Willingness to comply to a whole-food plant-based diet for 4 weeks

• Willingness to participate in a total of 3 blood drawings

Locations
Other Locations
Germany
Klinikum der Technischen Universität München (Klinikum rechts der Isar)
RECRUITING
München
Contact Information
Primary
Maike Buchner-Mayr, PD Dr.
Maike.Buchner@tum.de
+498941409255
Backup
Anna Herr, MSc
Anna.Herr@tum.de
+498941404159
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2028-06-30
Participants
Target number of participants: 50
Treatments
Experimental: Dietary intervention
All participants will receive nutrition counselling and partake in the WFPB diet for 4 weeks. Participants will be asked to keep a food diary.
Sponsors
Leads: Technical University of Munich

This content was sourced from clinicaltrials.gov