• Patients must have a diagnosis of Fanconi anemia

• Patients must have one of the following hematologic diagnoses:

‣ Severe Aplastic Anemia (SAA), with bone marrow cellularity of \<25% OR Severe Isolated Single Lineage Cytopenia and at least one of the following features:

• Platelet count \<20 x 109/L or platelet transfusion dependence\*

∙ ANC \<1000 x 109/L

∙ Hgb \<8 gm/dl or red cell transfusion dependence\*

⁃ Myelodysplastic Syndrome (MDS) (based on WHO or IPSS Classification

⁃ Acute Myelogenous Leukemia (untreated, in remission or with refractory or relapsed disease)

• Donors will be either human leukocyte antigen (HLA) compatible unrelated or HLA-genotypically matched related donors (no fully matched sibling donor).

• Patients and donors may be of either gender or any ethnic background.

• Patients must have a Karnofsky adult, or Lansky pediatric performance scale status \> 70%.

• Patients must have adequate physical function measured by:

‣ Cardiac: asymptomatic or if symptomatic then 1) left ventricular ejection fraction (LVEF) at rest must be \> 50% and must improve with exercise or 2) Shortening Fraction \> 29%

⁃ Hepatic: \< 5 x upper limit of normal (ULN) alanine transaminase (ALT) and \< 2.0 mg/dl total serum bilirubin.

⁃ Renal: serum creatinine \<1.5 mg/dl or if serum creatinine is outside the normal range, then CrCl \> 50 ml/min/1.73 m2

⁃ Pulmonary: asymptomatic or if symptomatic, DLCO \> 50% of predicted

• Each patient must be willing to participate as a research subject and must sign an informed consent form.

• Female patients and donors must not be pregnant or breastfeeding at the time of signing consent. Women must be willing to undergo a pregnancy test prior to transplant and avoid becoming pregnant while on study.