The Effects of Metabolic Syndrome and Its Components on Cognitive Performance and Physical Activity Level in Middle-age Individuals

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Metabolic syndrome (MetS) increases the risk of developing diabetes and cardiovascular disease risk factors that are linked with each other, which is a metabolic dysfunction, which contains a combination of multiple. It is known that METS plays a role in the development of many diseases such as cardiovascular diseases, stroke, cancer, Alzheimer's. Studies have revealed that neuroinflammation, oxidative stress, abnormal lipid metabolism and impaired vascularization, which play a role in the pathogenesis of MetS, affect the structure of the brain and cognition. Atherosclerosis of the carotid artery, increased brain atrophy and white matter damage are potential explanatory mechanisms that lead to an impact on cognitive skills in patients with MetS. In addition, the existence of MetS components such as obesity, diabetes, hypertension alone also negatively affects cognitive functions, and the level of cognitive influence also increases as the number of components an individual has increases. The literature reports that learning, executive functions, processing speed, attention/working memory and global cognitive functions are affected in individuals with MetS, but no consensus has been reached on this issue. Some studies say that MetS causes a significant decrease in cognitive functions, while some studies indicate that this difference is not significant. The aim of our study is to proof the relationship between MetS and cognitive functions with metabolic syndrome components. H1:There is a relationship between the MetS and cognitive functions.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:

• being between the ages of 18-50

• Having been educated for at least 5 years and know how to read and write

• Having been diagnosed with MetS by meeting 3 of the NCEP-ATP III criteria (for participants in the MetS Group)

• To have a biochemistry test performed within the last 6 months (for the Healthy Group)

• Not having any MetS components (For the Healthy Group)

Locations
Other Locations
Turkey
Bezmialem Vakif University
RECRUITING
Istanbul
Contact Information
Primary
Aysenur Erekdag, MSc
aysenurerekdag@gmail.com
+905548959013
Time Frame
Start Date: 2023-02-20
Estimated Completion Date: 2025-05
Participants
Target number of participants: 82
Treatments
MetS Group
it consists of volunteer participants diagnosed with MetS between the ages of 18 and 50. All assessments will be applied to the participants by two different researchers at the same time.
Control Group
it will consist of healthy individuals aged 18-50 who do not have any health problems and have volunteered to participate in the study who have undergone a health check within the last 6 months.
Sponsors
Leads: Istanbul University - Cerrahpasa

This content was sourced from clinicaltrials.gov