Assessing the Impact of Diastolic Dysfunction on the Presence of Symptoms in Patients with Primary Mitral Regurgitation.

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The current American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend surgery in patient with mitral regurgitation (MR) based on 1) the severity of MR and 2) the presence or absence of symptoms. Studies have shown that Cardiovascular Magnetic Resonance (CMR) is an accurate method to quantify the severity of MR. However, studies have also shown that symptoms are not necessarily related to the presence of symptoms. Thus, there appears to be a disconnect between the severity of MR and symptoms. Recent analysis of our data has shown that females and older patients with smaller ventricles, lower stroke volumes, and lower regurgitant volume relative to regurgitant fraction tend to be symptomatic. These findings suggest that decreased left ventricular compliance, i.e. diastolic dysfunction, may play an important role as an etiology of symptoms in patients with mitral regurgitation. The aim of this study is to study the presence of diastolic dysfunction in patients with MR and its association with symptom burden and exercise capacity.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Healthy Volunteers: f
View:

• Age \>=18 years of age

• Able to give informed consent

• Primary (degenerative) mitral regurgitation

• LVEF \>=50%

• Undergoing cardiac catheterization

• Able to exercise on a treadmill

Locations
United States
New Jersey
Morristown Medical Center
RECRUITING
Morristown
Contact Information
Primary
Medical Director, Cardiovascular Imaging, MD
seth.uretsky@atlantichealth.org
9739715597
Time Frame
Start Date: 2025-01-02
Estimated Completion Date: 2027-05-02
Participants
Target number of participants: 40
Treatments
Mitral Regurgitation
Patients with mitral regurgitation undergoing a left heart catheterization prior to mitral valve surgery or mitral valve clip.
Sponsors
Leads: Atlantic Health System

This content was sourced from clinicaltrials.gov