Precision Medicine for Dilated Cardiomyopathy-Cardiac Magnetic Resonance to Identify Early Family Phenotypes
The Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Study is an ancillary study from the parent study, DCM Precision Medicine Study. The rationale for the DCM-CMR study is to leverage cardiac magnetic resonance (CMR) imaging to detect earliest findings of DCM in the at-risk family members enrolled into the parent study.
• The FDR's proband was enrolled in the DCM Precision Medicine Study at 1 of 9 participating sites, or exceptions granted by study PI.
• The FDR's proband has had one or more variants identified, including P, LP and VUS.
• The FDR is able report to one of the participating sites for study enrollment.
• The FDR has no current contraindication for CMR (glomerular filtration rate (GFR) \<30 mL/min/1.73 m2, non-compatible device implant, or allergy to gadolinium contrast).
• The FDR has had no prior heart transplant.
• The FDR is ≥18 years of age.
• All races/ethnicity
• Ability to give informed consent.
• Ability to communicate in English.
⁃ Subject is not pregnant (CMR may be conducted 3-6 months post delivery)
⁃ Willingness to participate in a family-based study (subject willing to interact with OSU).