Clinical, Instrumental, and Molecular (Circulating and Tissue microRNAs) Characterization of Patients With Cardiomyopathy to Identify Critical Patients With Severe Organ Failure to be Candidates for Cardiac Transplantation

Status: Recruiting
Location: See all (3) locations...
Study Type: Observational
SUMMARY

The study aims to identify new diagnostic and prognostic markers for CMP that can help predict disease progression. In particular, the study will focus on microRNAs (miRNAs) and spatial transcriptomics, which are emerging techniques that may provide insights into the underlying disease mechanisms. By understanding these markers, the investigators hope to improve the way the investigators diagnose and manage CMP, particularly in terms of predicting progression to heart failure or heart transplantation. The study will evaluate patients with hypertrophic cardiomyopathy (e.g., sarcomeric forms, Anderson-Fabry disease, AL, and TTR cardiac amyloidosis), dilated cardiomyopathy and arrhythmogenic cardiomyopathy. These patients will undergo clinical evaluations, including ECG, echocardiograms, CMR, biopsy analysis, and genetic testing, as well as molecular studies such as transcriptomics and miRNA analysis. This comprehensive approach aims to identify potential new biomarkers for diagnosing and predicting the disease course.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Healthy Volunteers: f
View:

• Patients diagnosed with CMP according to current international guidelines

• Age ≥ 12 years at the time of diagnosis

• Obtaining informed consent from the patient and the parent or legal guardian (in the case of patients aged \< 18 years)

Locations
Other Locations
Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna
RECRUITING
Bologna
Azienda Ospedaliero-Universitaria Careggi di Firenze
NOT_YET_RECRUITING
Florence
Dipartimento di Scienze Toraciche Cardiovascolari, Fondazione Policlinico Universitario A. Gemelli IRCSS di Roma
NOT_YET_RECRUITING
Roma
Contact Information
Primary
Elena Biagini, MD, PhD
elena.biagini@aosp.bo.it
+39051214483
Backup
Silvia Palmieri, M. Sc.
silvia.palmieri@aosp.bo.it
+39051214483
Time Frame
Start Date: 2023-02-13
Estimated Completion Date: 2027-12-14
Participants
Target number of participants: 700
Sponsors
Leads: IRCCS Azienda Ospedaliero-Universitaria di Bologna

This content was sourced from clinicaltrials.gov