A Novel Raman Spectroscopy-Based Method for Pan-Cancers Early Diagnosis Supported by Deep Learning: A Prospective, Single-Arm, Multicentre Study

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening. The study includes healthy individuals, patients at risk of cancer, and patients with diagnosed cancers. The main questions it aims to answer are: * Evaluating the deep-learning model's accuracy and specificity in identifying cancer-specific features in Raman spectral data and determining whether this method can accurately classify patients based on risk. * Identifying which model is more adaptable to the Raman spectrum * Providing an interpretable analysis of the model-generated diagnosis Participants are already being diagnosed and follow-up to determine the type of cancer.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
View:

• Histopathological diagnosis of malignant tumors, including colorectal cancer, gastric cancer, hepatic cancer, pancreatic cancer, and esophageal cancer.

• Patients in normal physiological conditions without any malignant tumors or precancerous lesions.

• Patients with malignant tumor without recieving any interventions, including chemotherapy, surgery, radiotherapy, immunotherapy or other anti-tumor treatments.

• Patients with a histopathological diagnosis of any precancerous lesions or non-malignant disease.

Locations
Other Locations
China
The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING
Hangzhou
The First Affiliated Hospital to Nanchang University
RECRUITING
Nanchang
The Second Affiliated Hospital to Nanchang University
RECRUITING
Nanchang
Huashan Hospital Affiliated to Fudan University
RECRUITING
Shanghai
Contact Information
Primary
Jiasheng Xu, MD
1821286450@qq.com
+86 18720996980
Time Frame
Start Date: 2022-09-01
Estimated Completion Date: 2025-07-28
Participants
Target number of participants: 600
Treatments
Normal Physiology
Patients without cancers or precancerous lesion
Colorectal Cancer
Patients diagnosed with colorectal cancer (Pre-intervention)
Gastric Cancer
Patients diagnosed with gastric cancer (Pre-intervention)
Hepatic Cancer
Patients diagnosed with hepatic cancer (Pre-intervention)
Oesophageal
Patients diagnosed with oesophageal cancer (Pre-intervention)
Pancreatic Cancer
Patients diagnosed with pancreatic cancer (Pre-intervention)
Gastric Ulcer
Patients with gastric ulcers without any cancer
Colorectal Adenoma
Patients with colorectal adenoma without any cancer
Liver Cirrhosis
Patients with liver cirrhosis without any cancer
Pancreatitis
Patients with pancreatitis without any cancer
Oesophagitis
Patients with oesophagitis without any cancer
Sponsors
Leads: Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborators: The First Affiliated Hospital of Nanchang University, Huashan Hospital, Second Affiliated Hospital of Nanchang University

This content was sourced from clinicaltrials.gov