Intratumoral Pressure, Intratumoral Partial Oxygen Pressure, and Inflammatory Cytokines in Antisecretory Factor Treatment of Glioblastoma

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The objective of this clinical trial is to investigate the effects of Salovum®, an egg yolk powder enriched with the endogenous protein antisecretory factor, in participants undergoing diagnostic biopsies for suspected glioblastoma. The primary questions the trial seeks to answer are: * Will Salovum® reduce intratumoral pressure? * Will Salovum® influence the release of inflammatory cytokines from tumor tissue? Additionally, the study will investigate the impact of Salovum® on intratumoral partial oxygen pressure and tumor volume. Researchers will: * Place probes for measuring intratumoral pressure, microdialysis, and partial oxygen pressure during a standard biopsy procedure. * Compare measurements from participants before and during ingestion of Salovum®. Participants will: * Have probes implanted during a surgical biopsy. * Ingest Salovum® 24 to 72 hours after the procedure.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Suspected glioblastoma

• Age 18-75 years

• Planned diagnostic biopsy

• Informed consent of subject

Locations
Other Locations
Sweden
Department of Neurosurgery, Skane University Hospital
RECRUITING
Lund
Contact Information
Primary
Peter Siesjö, MD, PhD.
peter.siesjo@skane.se
+46705655778
Backup
Erik Ehinger, MD
erik.ehinger@med.lu.se
46707970783
Time Frame
Start Date: 2024-10-07
Estimated Completion Date: 2026-11
Participants
Target number of participants: 10
Treatments
Experimental: Salovum
Ingestion of Salovum during 48 hours starting 24 hours after diagnostic biopsy
Sponsors
Collaborators: Region Skane, Lund University
Leads: Peter Siesjö

This content was sourced from clinicaltrials.gov