The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections
The study is designed as an international, multicenter prospective cohort study. Patients with presumed glioblastoma (GBM) in- or near eloquent areas on diagnostic MRI will be selected by neurosurgeons. Patients will be treated following one of three study arms: 1) a craniotomy where the resection boundaries for motor or language functions will be identified by the awake mapping technique (awake craniotomy, AC); 2) a craniotomy where the resection boundaries for motor functions will be identified by asleep mapping techniques (MEPs, SSEPs, continuous dynamic mapping); 3) a craniotomy where the resection boundaries will not be identified by any mapping technique (no mapping group). All patients will receive follow-up according to standard practice.
• Age ≥18 years and ≤ 90 years
• Tumor diagnosed as GBM on MRI as assessed by the neurosurgeon
• Tumors situated in or near eloquent areas; motor cortex, sensory cortex, subcortical pyramidal tract, speech areas or visual areas as indicated on MRI (Sawaya Grading II and II)
• The tumor is suitable for resection (according to neurosurgeon)
• Written informed consent