Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Neurovascular uncoupling (NVU) represents a major source of potential bias for the identification of eloquent brain regions through activation procedures in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Same region shows proper pattern in glucose metabolism in victiny of brain lesions, investigated with positron emitted tomography with radiolabeled glucose (PET-FDG) This research project aims at investigating the mechanisms of NVU by using a multimodal noninvasive imaging approach in neurosurgical patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:
• patients in the study include prior imaging showing a potentially resectable intra-cerebral mass lesion. Patient has to be included before surgery, chemotherapy and radiation
Locations
Other Locations
Belgium
HUB-Erasme Hospital
RECRUITING
Brussels
Contact Information
Primary
Thibault Vanbutsele
thibault.vanbutsele@hubruxelles.be
25558167
Time Frame
Start Date: 2025-02-17
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 40
Treatments
Experimental: Glioma patient
As compared to the pre-surgical evaluation that brain tumor patients routinely undergo in our institution, patients are asked to undergo some additional examinations.
Related Therapeutic Areas
Sponsors
Leads: Erasme University Hospital