Prospective Cohort for the sEcoNDary Prevention of Ventricular Tachycardia in Patients With Cardiomyopathies (END-VT) Study

Status: Recruiting
Location: See all (3) locations...
Study Type: Observational
SUMMARY

Ventricular tachycardia (VT) is a life-threatening cardiac rhythm disturbance which leads to sudden cardiac death (SCD), ventricular fibrillation, electrical storm, hemodynamic collapse, and syncope. VT patients with cardiomyopathy (diseased/scarred cardiac muscle) have the highest risk of SCD (\<1-4%) and recurrent VTs (15-35%). Although an implantable cardiac defibrillator (ICD) is the most effective treatment option to prevent SCD, it does not eliminate it. Without VT prevention, recurrent VT and ICD shocks may increase the risk of heart failure and death. The primary objective is to determine the optimal treatment strategy to maximize event-free survival among cardiomyopathy patients with ventricular tachycardia (VT) by the creation of a prospective, multicenter, longitudinal cohort. Also, the investigators will evaluate the epidemiology of VT, adherence to guidelines, safety, effectiveness, and cost-effectiveness of current treatment options for secondary prevention of VT in the real-world Canadian VT population.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Documented sustained ventricular arrhythmia (\>30 seconds as documented by an ECG, cardiac monitor, AED, and/or intracardiac pacemaker/ICD electrograms (EGMs);

• First (new) diagnosis of VT;

• Presence of or plan for ICD implant during index hospitalization;

• Diagnosis of cardiomyopathy (ie. ICM, hypertrophic, dilated, restrictive, arrhythmogenic cardiomyopathy, or other scar),

• ICD clinic follow-up planned, and

• Age \>18 years old

Locations
Other Locations
Canada
QEII Health Science Centre
RECRUITING
Halifax
Montreal Heart Institute,
RECRUITING
Montreal
Providence Health Care Society
RECRUITING
Vancouver
Contact Information
Primary
John L Sapp, MD, FRCPC
john.sapp@nshealth.ca
902-473-4272
Backup
Suzanne E Greeley, BSCN
suzanne.greeley@nshealth.ca
902-473-2149
Time Frame
Start Date: 2024-01-12
Estimated Completion Date: 2029-04-30
Participants
Target number of participants: 2454
Sponsors
Leads: Nova Scotia Health Authority
Collaborators: Maritime Heart Centre

This content was sourced from clinicaltrials.gov