Influence of Obesity on Endogenous Oxalate Synthesis
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
There is increasing evidence that obesity is associated with increased urinary oxalate excretion, an important risk factor for calcium oxalate stone formation. By the administration of a controlled low oxalate diet the investigators will estimate endogenous oxalate synthesis in both non-obese and obese non-kidney-stone forming adults. This study seeks to thusly increase the understanding of the relationships between obesity and endogenous oxalate synthesis to serve as a platform to develop novel therapies for stone prevention.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:
• Age 25-60 years
• Body Mass Index (BMI) \<50
Locations
United States
Alabama
University of Alabama at Birmingham
RECRUITING
Birmingham
Contact Information
Primary
Sonia Fargue, MD PhD
sfargue@uab.edu
205-934-0169
Time Frame
Start Date: 2019-05-24
Estimated Completion Date: 2026-08-01
Participants
Target number of participants: 40
Treatments
Active_comparator: 20-24.9 BMI
Participants with a BMI that falls between 20 and 24.9 who will receive the controlled diet
Active_comparator: 25-29.9 BMI
Participants with a BMI that falls between 25 and 29.9 who will receive the controlled diet
Active_comparator: 30-34.9 BMI
Participants with a BMI that falls between 30 and 34.9 who will receive the controlled diet
Active_comparator: 35-39.9 BMI
Participants with a BMI that falls between 35 and 39.9 who will receive the controlled diet
Active_comparator: 40-44.9 BMI
Participants with a BMI that falls between 40 and 44.9 who will receive the controlled diet
Active_comparator: 45-50 BMI
Participants with a BMI that falls between 45 and 50 who will receive the controlled diet.
Related Therapeutic Areas
Sponsors
Leads: University of Alabama at Birmingham