The Genetics of Neuroendocrine Reproductive Disorders and of the Cleft Lip and/or Palate
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and/or palate.
Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
View:
• hypogonadotropic hypogonadism
• Kallmann syndrome
• adult-onset hypogonadotropic hypogonadism
• hypothalamic amenorrhea
• polycystic ovarian syndrome
• primary gonadal failure
• precocious puberty
• cleft lip/palate
• family members of the above groups
Locations
Other Locations
Switzerland
Centre Hospitalier Universitaire Vaudois (CHUV)
RECRUITING
Lausanne
Contact Information
Primary
Emmanuelle Paccou
emmanuelle.paccou@chuv.ch
+41 79 556 60 13
Backup
Michela Adamo, MD
michela.adamo@chuv.ch
+41 079 556 85 14
Time Frame
Start Date: 2012-03
Estimated Completion Date: 2030-03
Participants
Target number of participants: 2000
Treatments
Patients
Patients with reproductive disorders with or without cleft lip/palate will be recruited for:~* completion of medical questionnaire and review of medical records~* family tree (including questions on reproductive disorders and cleft lip/palate)~* specimen collection (DNA/RNA) from: serum/plasma/saliva/urine/buccal swab/hair follicles/sperm/skin biopsy~* smell testing~* hearing test~* bone density~* brain MRI~* kidney, testicular/ovarian ultrasound
Family members
Family members of Patients will be recruited for:~* completion of medical questionnaire~* specimen collection (DNA/RNA) from: serum/plasma/saliva/urine/buccal swab/hair follicles/sperm/skin biopsy~* smell testing
Related Therapeutic Areas
Sponsors
Collaborators: Swiss National Science Foundation
Leads: Centre Hospitalier Universitaire Vaudois