Investigating the Efficiency of Autologous Platelet Rich Plasma Intraovarian Infusion on Improving Ovarian Functionality in Poor Ovarian Response Patients
Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic sperm injection (ICSI) treatment.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 35
Maximum Age: 47
Healthy Volunteers: t
View:
∙ Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following):
• Age ≥ 40 years
• AMH \< 1.1 ng/ml OR AFC \< 7
• ≤ 3 oocytes with a conventional stimulation protocol
‣ Discontinuation of any complementary/adjuvant treatment including hormone replacement and acupuncture, for at least three months prior to recruitment.
⁃ Willing to comply with study requirements
Locations
Other Locations
Greece
Genesis Athens Clinic
RECRUITING
Athens
Contact Information
Primary
Agni Pantou, M.D
agni.pantou@genesisathens.gr
+306974447702
Backup
Konstantinos Pantos, M.D., Ph.D
info@pantos.gr
+302106894326
Time Frame
Start Date: 2019-01-23
Estimated Completion Date: 2026-01-31
Participants
Target number of participants: 100
Treatments
Experimental: Experimental: Group of participants receiving PRP treatment
Women presenting with POR, treated with autologous PRP intraovarian infusion during the mid-luteal phase, undergoing a subsequent stimulated fresh ET-ICSI cycle on the first month following PRP infusion
No_intervention: Control Group: Group of participants receiving standard protocol
Women presenting with POR undergoing a stimulated fresh ET-ICSI cycle
Related Therapeutic Areas
Sponsors
Collaborators: National and Kapodistrian University of Athens
Leads: Genesis Athens Clinic