Investigating Improvement of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in Poor Responders
Who is this study for? Patients presenting with poor ovarian response
What treatments are being studied? Platelet-rich plasma
Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
Autologous PRP intra ovarian infusion may improve ovarian response, patients' hormonal profile as well as fresh embryo transfer (ET)-ICSI cycles' outcome in patients presenting with Poor Ovarian Response (POR).
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 35
Maximum Age: 47
Healthy Volunteers: t
View:
• Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following)
• Age ≥ 40 years
• AMH \< 1.1 ng/ml OR AFC \< 7
• ≤ 3 oocytes with a conventional stimulation protocol)
• Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.
• Willing to comply with study requirements
Locations
Other Locations
Greece
Genesis AC
RECRUITING
Athens
Contact Information
Primary
Mara Simopoulou, PhD
marasimopoulou@hotmail.com
+306979234100
Backup
Agni Pantou, MD, PhD Candidate
agni.pantou@genesisathens.gr
+306974447702
Time Frame
Start Date: 2019-05-06
Estimated Completion Date: 2025-08-30
Participants
Target number of participants: 100
Treatments
Experimental: Group of participants receiving PRP treatment
Women presenting with POR, treated with autologous PRP intra ovarian infusion and undergoing a subsequent fresh ET-ICSI cycle on the third month of the follow-up period.
Placebo_comparator: Control Group: participants receiving Platelet Free Plasma
Women presenting with POR, treated with autologous PFP intra ovarian infusion and undergoing a subsequent fresh ET-ICSI cycle on the third month of the follow-up period
Related Therapeutic Areas
Sponsors
Collaborators: National and Kapodistrian University of Athens
Leads: Genesis Athens Clinic