Determine the Contribution of Paracellular GI Oxalate Absorption in Obese and Roux-en-Y Gastric Bypass Kidney Stone Patients
This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.
⁃ Post-Roux-en-Y gastric bypass stone formers:
• Age 18-70
• Previous history of Roux-en-Y gastric bypass
• History of at least one calcium-based kidney stone after surgery
• Pre-protocol urine oxalate above the lab normal range (50mg/day)
⁃ Obese stone formers:
• Age 18-70
• Body mass index (BMI) \>=30kg/m2
• History of at least one calcium-based kidney stone
• Pre-protocol urine oxalate above the lab normal range (50mg/day)
⁃ Non-obese stone formers:
• Age 18-70, BMI between 18.5-29.9 kg/m2
• History of at least one calcium-based kidney stone