Dr. Sacha F. Charles

Robert Mendelson is a Cardiologist and an Internal Medicine provider in Richmond Hills, New York. Dr. Mendelson is rated as a Distinguished provider by MediFind in the treatment of Long QT Syndrome. His top areas of expertise are Jervell Lange-Nielsen Syndrome (JLNS), Timothy Syndrome, Long QT Syndrome 5, and Long QT Syndrome.

Mark Nachamie is an Internal Medicine provider in New York, New York. Dr. Nachamie is rated as a Distinguished provider by MediFind in the treatment of Long QT Syndrome. His top areas of expertise are Long QT Syndrome 3, Jervell Lange-Nielsen Syndrome (JLNS), Long QT Syndrome, and Timothy Syndrome.

"Regulation of Cardiac Ion Channel Function: The Na+ channel (SCN5A, LQT3) and two K+ channels, HERG (LQT2) and KVLQT1 (LQT1) are linked to the inherited Long QT Syndrome and are responsible for cardiac action potential initiation and termination for each heart beat. Appropriate activation of these channels terminates each action potential allowing the next heart beat to occur in a normal fashion. Macromolecular signaling complexes involving channels may serve multiple functions including assembly, trafficking, targeting, and recycling of the channel proteins. Dynamic, beat-to-beat regulation of cardiac ion channels is likely to be precisely controlled given that both acquired and inherited ventricular arrhythmias are usually episodic and precipitated by some stimulus or stress. Moreover, such regulation may underlie the responses to cardiovascular challenges and stresses that eventually lead to maladaptive ""electrical remodeling"" with cardiac arrhythmias.". Dr. Mcdonald is rated as an Advanced provider by MediFind in the treatment of Long QT Syndrome. His top areas of expertise are Long QT Syndrome, Cardiomyopathy, Dilated Cardiomyopathy (DCM), and Familial Hypertrophic Cardiomyopathy.