Italian Registry of Families At Risk of Pancreatic Cancer
IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.
• individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree
• subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
• subjects suffering from FAMMM Syndrome
• subjects suffering from Peutz-Jeghers Syndrome
• subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis
• subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
• 45 years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases
• 40 years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer
• 30 years for subjects suffering from FAMMM, Peutz-Jeghers syndrome