Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis
The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.
• Patients with an indication for initial diagnostic PBR on native kidney
• 18 ans ≥ Age ≤ 90 ans
• Affiliation to french health insurance
• Patient having given consent
⁃ For the ANCA vasculitis group:
⁃ • Diagnosis of ANCA vasculitis retained on renal biopsy with ANCA anti-proteinase 3 (PR3) or ANCA anti-myeloperoxidase (MPO)
⁃ For the control groups:
⁃ • Diagnosis retained after the renal biopsy
• Interstitial Nephritis
• Or glomerular nephropathy such as minimal change nephropathy
• Or Segmental hyalinosis in itscollapsing form
• Or Extramembranous Glomerulopathy,
• Or glomerulopathy with mesangial IgA deposits
• Or diabetic nephropathy.