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Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:

• Patients with an indication for initial diagnostic PBR on native kidney

• 18 ans ≥ Age ≤ 90 ans

• Affiliation to french health insurance

• Patient having given consent

⁃ For the ANCA vasculitis group:

⁃ • Diagnosis of ANCA vasculitis retained on renal biopsy with ANCA anti-proteinase 3 (PR3) or ANCA anti-myeloperoxidase (MPO)

⁃ For the control groups:

⁃ • Diagnosis retained after the renal biopsy

• Interstitial Nephritis

• Or glomerular nephropathy such as minimal change nephropathy

• Or Segmental hyalinosis in itscollapsing form

• Or Extramembranous Glomerulopathy,

• Or glomerulopathy with mesangial IgA deposits

• Or diabetic nephropathy.

Locations
Other Locations
France
Georges-Pompidou European Hospital, AP-HP
RECRUITING
Paris
Contact Information
Primary
Maxime BRUSSIEUX
maxime.brussieux@aphp.fr
+33 1 44 84 17 89
Backup
Laura LE MAO
laura.le-mao@aphp.fr
+33 1 56 09 54 97
Time Frame
Start Date: 2025-11-03
Estimated Completion Date: 2029-11-02
Participants
Target number of participants: 146
Treatments
ANCA Associated Vasculitis
Case
Extramembranous Glomerulopathy
Control
Nephrotic Syndrome, Minimal Change
Control
Interstitial Nephritis
Control
IgA Nephropathy
Control
Segmental Hyalinosis
Control
Diabetic Nephropathy
Control
Sponsors
Collaborators: National Research Agency, France, Institut National de la Santé Et de la Recherche Médicale, France, Ministry of Health, France
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov

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