Mononeuritis Multiplex Clinical Trials

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Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care for Emergency Department Patients With Low Back Pain and Sciatic Radiculopathy: A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Other, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to compare transgluteal sciatic nerve block to standard of care to treat sciatic back pain in adult patients who present to the emergency department. The main question it aims to answer is: Is a transgluteal sciatic nerve block better than standard of care in improving pain in ER patients with sciatic back pain? If there is a comparison group: Researchers will compare patients who receive transgluteal sciatic nerve blocks to patients who receive standard of care to see if pain scores improve in ER patients with sciatic back pain. Participants will be randomized into the transgluteal sciatic nerve block group or the control group (standard of care). Participants will be asked to answer questions about their pain and will be asked to walk a timed short distance.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adults aged 18 years and older

• Presentation to ED with:

• Acute or acute-on-chronic pain consistent with sciatica, defined as unilateral lumbosacral radicular pain radiating from the lower back or gluteal region to the posterior leg, may extend distal to the knee.

• Pain score ≥ 5/10 on Numeric Rating Scale (NRS)

Locations
United States
California
University of California, San Francisco
RECRUITING
San Francisco
Contact Information
Primary
Tianyu Tang, MD
tianyu.tang@ucsf.edu
628-247-7578
Backup
Felipe Ocampo, MD
felipe.ocampo@ucsf.edu
Time Frame
Start Date: 2026-04-25
Estimated Completion Date: 2027-01-31
Participants
Target number of participants: 100
Treatments
Experimental: Transgluteal sciatic nerve block
Patients will receive an ultrasound-guided transgluteal sciatic nerve block with 10-20 mL of 0.2% ropivacaine injected around the affected sciatic nerve at the level of the greater trochanter.
Active_comparator: Standard of care
Standard ED analgesic management per departmental protocols (oral/IV NSAIDs, acetaminophen, opioids, muscle relaxants).
Sponsors
Leads: University of California, San Francisco

This content was sourced from clinicaltrials.gov