Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B) Overview

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Learn About Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)

View Main Condition: Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome)

What is the definition of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)?
Mucopolysaccharidosis type IIIB (MPS IIIB) is an genetic disorder that makes the body unable to break down large sugar molecules called glycosaminoglycans (GAGs, formerly called mucopolysaccharides). Specifically, people with this condition are unable to break down a GAG called heparan sulfate. Affected individuals can have severe neurological symptoms, including progressive dementia, aggressive behavior, hyperactivity, seizures, deafness, loss of vision, and an inability to sleep for more than a few hours at a time. MPS IIIB is caused by alterations in the NAGLU gene. This gene provides the instructions for producing an enzyme called N-alpha-acetylglucosaminidase, which is needed to completely break down heparan sulfate. MPS IIIB is inherited in an autosomal recessive manner.
What are the alternative names for Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)?
  • Mucopolysaccharidosis type IIIB
  • MPS 3B
  • MPS IIIB
  • Mucopoly-saccharidosis type 3B
  • N-acetyl-alpha-d-glucosaminidase deficiency
  • Sanfilippo syndrome B
Who are the top Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B) Local Doctors?
Dr. Hesam Hekmatjou
Family Medicine
Dr. Hesam Hekmatjou
Family Medicine

Providence Facey Medical Foundation

191 S Buena Vista St, Suite 100, 
Burbank, CA 
 (22.1 mi)
818-869-7600
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Hesam Hekmatjou is a Family Medicine provider in Burbank, California. Dr. Hekmatjou and is rated as an Experienced provider by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). His top areas of expertise are Mucopolysaccharidosis Type 3A (MPS IIIA, Sanfilippo Syndrome A), Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome), and Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B).

Paul R. Harmatz
Dr. Paul R. Harmatz
Pediatric Gastroenterology | Gastroenterology
Dr. Paul R. Harmatz
Pediatric Gastroenterology | Gastroenterology

UCSF Benioff Children's Hospital Gastroenterology Clinic

744 52nd St, 5th Floor, 
Oakland, CA 
 (314.5 mi)
510-428-3058
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Paul Harmatz is a Gastroenterologist and a Pediatric Gastroenterologist in Oakland, CA. Dr. Harmatz and is rated as a Distinguished provider by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). His top areas of expertise are Mucopolysaccharidoses (MPS), Mucopolysaccharidosis Type 6 (MPS VI, Maroteaux-Lamy Syndrome), Mucopolysaccharidosis Type 2 (MPS II, Hunter Syndrome), and Mucopolysaccharidosis Type 4 (MPS IV, Morquio Syndrome).

 
 
 
 
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Dr. Nicola Longo
Medical Genetics | Pediatrics
Dr. Nicola Longo
Medical Genetics | Pediatrics

Uc Regents

10833 Le Conte Ave, 
Los Angeles, CA 
 (26.2 mi)
Languages Spoken:
English, Hindi, Italian, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Nicola Longo is a Medical Genetics specialist and a Pediatrics provider in Los Angeles, California. Dr. Longo and is rated as an Advanced provider by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). His top areas of expertise are Primary Carnitine Deficiency, Gaucher Disease Type 1, Urea Cycle Disorders (UCD), and Phenylketonuria (PKU). Dr. Longo is currently accepting new patients.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center