Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
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Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B) Overview

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Learn About Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)

View Main Condition: Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome)

What is the definition of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)?
Mucopolysaccharidosis type IIIB (MPS IIIB) is an genetic disorder that makes the body unable to break down large sugar molecules called glycosaminoglycans (GAGs, formerly called mucopolysaccharides). Specifically, people with this condition are unable to break down a GAG called heparan sulfate. Affected individuals can have severe neurological symptoms, including progressive dementia, aggressive behavior, hyperactivity, seizures, deafness, loss of vision, and an inability to sleep for more than a few hours at a time. MPS IIIB is caused by alterations in the NAGLU gene. This gene provides the instructions for producing an enzyme called N-alpha-acetylglucosaminidase, which is needed to completely break down heparan sulfate. MPS IIIB is inherited in an autosomal recessive manner.
What are the alternative names for Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)?
  • Mucopolysaccharidosis type IIIB
  • MPS 3B
  • MPS IIIB
  • Mucopoly-saccharidosis type 3B
  • N-acetyl-alpha-d-glucosaminidase deficiency
  • Sanfilippo syndrome B
Who are the top Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B) Local Doctors?
Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Dr. Patricia I. Dickson
Medical Genetics | Pediatrics
Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Dr. Patricia I. Dickson
Medical Genetics | Pediatrics
Referral may be required

Washington University

1 Childrens Pl, 
Saint Louis, MO 
314-454-6000
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Patricia Dickson is a Medical Genetics specialist and a Pediatrics provider practicing medicine in Saint Louis, Missouri. Dr. Dickson is rated as an Elite provider by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). She is also highly rated in 12 other conditions, according to our data. Her clinical expertise encompasses Mucopolysaccharidosis Type 1 (MPS I, Hurler Syndrome), Mucopolysaccharidoses (MPS), Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome), and Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). Dr. Dickson is currently accepting new patients.

Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Referral may be required
Naples, IT 

Valeria De Pasquale practices practicing medicine in Naples, Italy. Ms. De Pasquale is rated as an Elite expert by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). She is also highly rated in 3 other conditions, according to our data. Her clinical expertise encompasses Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B), Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome), Mucopolysaccharidoses (MPS), and Multiple Sulfatase Deficiency.

 
 
 
 
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Experienced in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Dr. John R. Windle
Cardiac Electrophysiology | Cardiology
Experienced in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Dr. John R. Windle
Cardiac Electrophysiology | Cardiology
Referral may be required

Heart And Vascular Center At Durham Outpatient Center

4400 Emile St., 
Omaha, NE 
402-559-8888
Experience:
47+ years
Languages Spoken:
English
See accepted insurances

John Windle is a Cardiologist and a Cardiac Electrophysiologist practicing medicine in Omaha, Nebraska. He has been practicing medicine for over 47 years. Dr. Windle is rated as an Experienced provider by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). He is also highly rated in 37 other conditions, according to our data. His clinical expertise encompasses Familial Ventricular Tachycardia, Atrioventricular Nodal Reentrant Tachycardia (AVNRT), Paroxysmal Supraventricular Tachycardia (PSVT), Cardiac Ablation, and Pacemaker Implantation.

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What are the latest Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B) Clinical Trials?
Longitudinal Study of Neurodegenerative Disorders
Longitudinal Study of Neurodegenerative Disorders
Enrollment Status: Recruiting
Publish Date: February 09, 2026
Intervention Type: Biological, Other

Summary: The purpose of this study is to understand the course of rare genetic disorders that affect the brain. This data is being analyzed to gain a better understanding of the progression of the rare neurodegenerative disorders and the effects of interventions.

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center