Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B) Overview

Save information for later
Sign Up

Learn About Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)

View Main Condition: Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome)

What is the definition of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)?
Mucopolysaccharidosis type IIIB (MPS IIIB) is an genetic disorder that makes the body unable to break down large sugar molecules called glycosaminoglycans (GAGs, formerly called mucopolysaccharides). Specifically, people with this condition are unable to break down a GAG called heparan sulfate. Affected individuals can have severe neurological symptoms, including progressive dementia, aggressive behavior, hyperactivity, seizures, deafness, loss of vision, and an inability to sleep for more than a few hours at a time. MPS IIIB is caused by alterations in the NAGLU gene. This gene provides the instructions for producing an enzyme called N-alpha-acetylglucosaminidase, which is needed to completely break down heparan sulfate. MPS IIIB is inherited in an autosomal recessive manner.
What are the alternative names for Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)?
  • Mucopolysaccharidosis type IIIB
  • MPS 3B
  • MPS IIIB
  • Mucopoly-saccharidosis type 3B
  • N-acetyl-alpha-d-glucosaminidase deficiency
  • Sanfilippo syndrome B
Who are the top Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B) Local Doctors?
Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Dr. Patricia I. Dickson
Medical Genetics | Pediatrics
Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Dr. Patricia I. Dickson
Medical Genetics | Pediatrics

Washington University

1 Childrens Pl, Suite 8116, 
Saint Louis, MO 
314-454-6000
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Patricia Dickson is a Medical Genetics specialist and a Pediatrics provider in Saint Louis, Missouri. Dr. Dickson is rated as an Elite provider by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). Her top areas of expertise are Mucopolysaccharidosis Type 1 (MPS I, Hurler Syndrome), Mucopolysaccharidoses (MPS), Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome), and Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). Dr. Dickson is currently accepting new patients.

Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Valeria De Pasquale
Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Valeria De Pasquale
Naples, IT 

Valeria De Pasquale practices in Naples, Italy. Ms. De Pasquale is rated as an Elite expert by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). Her top areas of expertise are Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B), Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome), Mucopolysaccharidoses (MPS), and Multiple Sulfatase Deficiency.

 
 
 
 
Learn about our expert tiers
Learn More
Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Brian W. Bigger
Elite in Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B)
Brian W. Bigger
Edinburgh, SCT, GB 

Brian Bigger practices in Edinburgh, United Kingdom. Mr. Bigger is rated as an Elite expert by MediFind in the treatment of Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B). His top areas of expertise are Mucopolysaccharidoses (MPS), Mucopolysaccharidosis Type 3 (MPS III, Sanfilippo Syndrome), Mucopolysaccharidosis Type 3A (MPS IIIA, Sanfilippo Syndrome A), Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B), and Bone Marrow Transplant.

View All Doctors
What are the latest Mucopolysaccharidosis Type 3B (MPS IIIB, Sanfilippo Syndrome B) Clinical Trials?
Longitudinal Study of Neurodegenerative Disorders
Longitudinal Study of Neurodegenerative Disorders
Enrollment Status: Recruiting
Publish Date: March 07, 2025
Intervention Type: Biological, Other

Summary: The purpose of this study is to understand the course of rare genetic disorders that affect the brain. This data is being analyzed to gain a better understanding of the progression of the rare neurodegenerative disorders and the effects of interventions.

Match to trials
Find the right clinical trials for you in under a minute
Get started
View All Clinical Trials
Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center