Overview
"Chen's primary area of research focuses on bone marrow transplantation (BMT), a highly complex and specialized aspect of pediatric oncology that, in recent years, has become an accepted form of therapy for an increasingly broad range of cancers. In addition to the myriad ways BMT is currently being utilized at Hopkins, Chen is working to refine novel approaches to the therapy and apply them to some of the toughest cases. ""One hypothesis is that, in patients receiving a transplant using their own stored stem cells, we can induce an immunologic response from their own cells that mimics the graft received from a healthy donor,"" Chen says. ""We're also excited about the ability to foster immune tolerance when the only available healthy donors aren't perfect matches for the patient."" In a quest to solve some of the rarest and most troubling treatment challenges facing pediatric oncology, Chen and fellow pediatric oncologists at Hopkins have joined forces with others around North America in the Pediatric Blood and Marrow Transplant Consortium. ""We're trying to develop multi-institutional studies to improve the effectiveness of BMT for cancer. The study we're working on now will help us to understand why some patients relapse in spite of BMT for acute myeloid leukemia,"" says Chen, who chairs the Oncology Strategy Group of this consortium. Chen also immerses himself in several Hopkins-based initiatives. Recently, he was named Chair of the Oncology Clinical Research Review Committee, a group mandated to oversee all patient-oriented research in the comprehensive cancer center to ensure it meets the center's standards of scientific merit and priority. He also chairs the Performance Improvement Committee. This multi-disciplinary group consists of physicians, nurses, and pharmacists who examine practical ways to reduce errors and improve patient outcomes. The committee recently joined forces with Hopkins' information technology professionals to apply a computerized order entry system—even to complex treatment protocols like chemotherapy. ""We've seen an amazing improvement; a number of potential medication errors decreased dramatically,"" Chen says. Currently, the committee is analyzing ways to reduce bloodstream infections in pediatric patients, which can create potentially life-threatening complications. Despite the hectic pace of Chen's professional life, he has managed to find a way to leave behind the stress of his job and bond with his own children. He and his sons began taking Kung Fu classes when his older son began middle school. He's since grown up and left for college, but Chen continues the practice as both a student and a teacher. Regardless of where Chen is, he's never too far removed from the challenges that await him at work. ""Sometimes, in the wee hours of the morning, I suddenly realize why a complication has occurred,"" he says.".
Dr. Chen is rated as an Experienced provider by MediFind in the treatment of Neuroepithelioma. His top areas of expertise are Acute Lymphoblastic Leukemia (ALL), Ganglioneuroblastoma, Leukemia, and Neuroblastoma.
His clinical research consists of co-authoring 60 peer reviewed articles and participating in 7 clinical trials. MediFind looks at clinical research from the past 15 years. In particular, he has participated in 4 clinical trials in the study of Neuroepithelioma.
Insurance
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Locations
1800 Orleans Street, Bloomberg 11N, Bloomberg 11N, Baltimore, MD 21287
Clinical Research
Clinical research consists of overseeing clinical studies of patients undergoing new treatments and therapies, and publishing articles in peer reviewed medical journals. Providers who actively participate in clinical research are generally at the forefront of the fields and aware of the most up-to-date advances in treatments for their patients.
7 Clinical Trials
Skip Viragh Outpatient Cancer Center
Dr. Matthias Holdhoff is a medical oncologist and co-director of the Brain Cancer Disease Group at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He is a professor of oncology, neurology and neurological surgery at Johns Hopkins University School of Medicine. Dr. Holdhoff’s expertise is in primary brain cancers and central nervous system lymphomas. He earned his medical degree from Freie Universität Berlin, received his doctorate degree at Charité University Medicine Berlin. Dr. Holdhoff completed residency training in internal medicine at Johns Hopkins Bayview Medical Center, followed by a fellowship in medical oncology at Johns Hopkins Hospital with research training at the Ludwig Center for Cancer Genetics and Therapeutics (Kinzler-Vogelstein lab). As a clinical investigator in neuro-oncology, his research is focused on novel trials and translational biomarker studies in malignant gliomas and primary central nervous system lymphomas. He has led and contributed to numerous clinical trials, publications and presentations. Dr. Holdhoff serves as the director of the solid tumor inpatient service at the Sidney Kimmel Comprehensive Cancer Center. He is passionately involved in mentoring and teaching of fellows, residents and students. He is the director of the UCNS-certified neuro-oncology fellowship program at Johns Hopkins, and he is a teaching attending physician for the Osler internal medicine residency program. Dr. Holdhoff is rated as an Elite provider by MediFind in the treatment of Neuroepithelioma. His top areas of expertise are Glioma, Glioblastoma, Astrocytoma, and Brain Tumor.
Skip Viragh Outpatient Cancer Center
Stuart Grossman, M.D., is a professor of oncology at the Johns Hopkins Kimmel Cancer Center. He has served as Principal Investigator and Director of the Central Operations office of the National Cancer Institute-funded phase I/II brain tumor consortia (New Approaches to Brain Tumor Therapy CNS Consortium and the Adult Brain Tumor Consortium) for the past 22 years. He has led many phase I, II, and III institutional and cooperative group translational and clinical brain cancer research projects. Dr. Grossman's expertise is in brain cancers, translational and clinical research, and directing large, multicenter, multidisciplinary clinical trial groups and training programs. Dr. Grossman was an intern and resident at Strong Memorial Hospital in Rochester, NY, and a fellow at the Johns Hopkins University School of Medicine. He received his M.D. from the University of Rochester. Dr. Grossman is rated as an Elite provider by MediFind in the treatment of Neuroepithelioma. His top areas of expertise are Astrocytoma, Glioblastoma, Glioma, and Gliomatosis Cerebri.
Inova Health Care Services
Adam Cohen is an Oncologist in Alexandria, Virginia. Dr. Cohen is rated as a Distinguished provider by MediFind in the treatment of Neuroepithelioma. His top areas of expertise are Embryonal Tumor with Multilayered Rosettes, Glioblastoma, Atypical Teratoid Rhabdoid Tumor (ATRT), Bone Marrow Aspiration, and Liver Embolization. Dr. Cohen is currently accepting new patients.
Areas of Expertise
MediFind evaluates expertise by pulling from factors such as number of articles a doctor has published in medical journals, participation in clinical trials, speaking at industry conferences, prescribing and referral patterns, and strength of connections with other experts in their field.
Learn more about MediFind’s expert tiers
- Experienced
- Acute Lymphoblastic Leukemia (ALL)Dr. Chen isExperienced. Learn about Acute Lymphoblastic Leukemia (ALL).
- Childhood Acute Myeloid LeukemiaDr. Chen isExperienced. Learn about Childhood Acute Myeloid Leukemia.
- Embryonal Tumor with Multilayered Rosettes
- GanglioneuroblastomaDr. Chen isExperienced. Learn about Ganglioneuroblastoma.
- Gliomatosis CerebriDr. Chen isExperienced. Learn about Gliomatosis Cerebri.
- Hodgkin LymphomaDr. Chen isExperienced. Learn about Hodgkin Lymphoma.