‣ 1\. Patients with B-cell lymphoproliferative disorders:

‣ 1a. In cases of B-cell lymphoproliferative disorders developed from lymphocyte precursors (ALL/LBL), the disease status satisfies one of the following criteria:

• Failure of induction (primary-refractory course or MOB persistence), absence of clinical and hematologic remission after first-line therapy,

• MOB persistence with achieved second and subsequent clinical and morphologic remissions,

• Early medullary or combined relapse if the duration of the first remission is not more than 12 months, provided the disease is stabilized,

• Confirmed MOB relapse,

• Second and subsequent relapses, including neurorelapse,

• Refractory disease course after two or more lines of chemotherapy,

• Relapsed or refractory disease after allo-HSCT with transplantation performed more than 100 days ago and more than 4 weeks after withdrawal of immunosuppressive therapy before inclusion.

⁃ b. In the case of Ph-positive ALL/LBL:

• Molecular relapse, advanced relapse, isolated neurorelapse, or refractory disease after the use of more than 2 lines of ITC.

• 1c. In cases of aggressive B-cell non-Hodgkin's lymphoma, disease status satisfies one of the following criteria:

• Absence of remission after 1-2 courses of intensive chemotherapy or in the presence of factors of unfavorable prognosis (TP53 mutation, co-expression of c-MYC and BCL2, abnormalities of c-MYC, BCL2, BCL6, and other genes),

• Disease progression on chemotherapy in the form of the appearance of a new lesion focus or increase of the initial focus by at least 50% during therapy,

• Relapse within 12-18 months after the end of chemotherapy, regardless of the presence or absence of factors of unfavorable prognosis,

• Resistance to 2 or more prior lines of therapy.

• 1d. In cases of indolent B-cell non-Hodgkin's lymphoma, disease status satisfies one of the following criteria:

• early relapse (POD 24) in patients with contraindications to auto-HSCT,

• absence of clinical and hematologic remission after 1 line of therapy in the presence of TR53 mutation,

• relapse in the presence of signs of transformation into aggressive lymphoma,

• resistance to the previously performed 2 or more lines of therapy. 2. Male or Female subjects aged 18-70 years (at the time of signing the informed consent form).

• 3\. CD19 antigen expression of ≥20% (for B-ALL) or presence of CD19 expressing tumor cell population (for lymphoma).

• 4\. ECOG 0-2 points. 5. Life expectancy of at least 12 weeks. 6. Absolute CD3+ lymphocyte count in peripheral blood greater than 0.1\*10\^9 cells/L.

• 7\. Preserved organ function, defined as:

• Lung function: absence of hypoxemia according to pulse oximetry (SrO2 \>91%) when breathing atmospheric air;

• Renal function: creatinine \<130 µmol/L or ICF \>60 ml/min per 1.73m2;

• Liver function: total bilirubin concentration less than 34 μmol/L, ALT concentration not exceeding more than 5 times the upper limit of reference values (except for Gilbert's syndrome);

• Cardiac function: stable hemodynamics and ejection fraction not less than 45%, absence of ejection in the pericardial cavity.

• 8\. Male or female patients with a very low probability of conception characterized by meeting at least one of the following criteria:

• Patient is not of reproductive potential. A female patient of no reproductive potential characterized by one of two criteria: (1) attainment of natural menopause (defined as 12 months of spontaneous amenorrhea in women \>45 years of age or 6 months of spontaneous amenorrhea with a serum FSH concentration characteristic of the postmenopausal range as determined by the laboratory) or (2) bilateral ovariectomy and/or hysterectomy or bilateral fallopian tube ligation at least 6 weeks before screening.

• The patient is of reproductive potential and agrees to abstain from sexual activity or to use (including partner use) an acceptable method of contraception for the planned duration of the study. Acceptable contraceptive methods are hormonal contraception, intrauterine contraceptive device (IUD), diaphragm with spermicide, contraceptive sponge, condom, and vasectomy (performed at least 6 weeks prior to screening).

• 9\. Consent for continued follow-up for 15 years from study inclusion. 10. Adequate central or peripheral vascular access for the apheresis procedure. 11. The patient understands the study procedures, available alternative therapies, and study risks and voluntarily agrees to participate by providing written informed consent.