Development of Computational Models to Predict the Short-, Medium- and Long-term Cartilage Degeneration and Pain for Patients With Early-stage Osteoarthritis or Anterior Cruciate Ligament Injury
Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY
Knee osteoarthritis is a complex condition, and selecting effective non-drug treatments like orthoses or exercise is often difficult and imprecise. This study will follow individuals with early-stage knee osteoarthritis or previous anterior cruciate ligament injury to develop computational models that predict cartilage degeneration and pain over time. The models will integrate data from medical imaging, movement analysis, muscle strength testing, pain assessments, questionnaires, and biomarkers to improve personalized treatment planning.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:
• Adults under 70 years
• ACL injury within the last year and planned for ACL reconstruction at inclusion
• Adults under 70 years
• ACL injury within the last year and with no plans for ACL reconstruction at inclusion
• Adults under 70 years
• Diagnosis of knee OA (Kellgren Lawrence (KL) grade 1, 2 and 3 (Kohn et al., 2016). If there is no X-ray that is a maximum of 1 year old, a new one is taken.
• Stress-related pain in the knee and knee stiffness
• Adults under 70 years
• Informed consent form signed
Locations
Other Locations
Denmark
Aalborg University
RECRUITING
Aalborg
Aalborg University Hospital
RECRUITING
Aalborg
Time Frame
Start Date:2024-09-26
Estimated Completion Date:2036-09-26
Participants
Target number of participants:105
Treatments
Knee OA
Participants diagnosed with early-stage knee osteoarthritis. Followed longitudinally to assess cartilage degeneration, pain, and biomarkers.
ACL reconstruction
Participants with a history of anterior cruciate ligament injury who have undergone reconstructive surgery. Monitored for cartilage health and OA progression.
ACL No reconstruction
Participants with anterior cruciate ligament injury who did not undergo reconstructive surgery. Observed over time for cartilage degeneration and symptoms.
Control for Knee OA group
Age- and sex-matched participants with no clinical or imaging signs of knee osteoarthritis. Serve as controls for the Knee OA group.
Control for ACL reconstruction group
Participants with no history of ACL injury or surgery, matched to the ACL reconstruction group. Used as controls.
Control for ACL No reconstruction group
Participants without knee injuries, matched to the ACL no reconstruction group. Serve as observational controls.