Somatosensory Phenotyping of Patients With ADPKD Using Quantitative Sensory Testing and Questionnaires

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Over 60% of patients with ADPKD suffer from pain, mostly in the abdomen, flank and back, often leading to the diagnosis. It is challenging to manage and cure the pain; approximately 39% of patients are not satisfied with their pain treatment, since the pain prevents them from doing various activities, affecting their quality of life. Pain can be present before enlargement of the kidneys, the source of the pain is often unknown and common analgesics are insufficient to manage the pain or cannot be taken due to renal impairment. By further investigating and characterizing the pain phenotype of the ADPKD population, pain management might be improved and alternative therapeutic approaches might be developed. In this clinical study, pain will be assessed in patients with ADPKD using Quantitative Sensory Testing (QST) on the dominant hand and the lower back, together with four questionnaires regarding pain and quality of life. These results will be compared with the somatosensory profile of matched healthy volunteers.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Healthy Volunteers: t
View:

⁃ Patients with ADPKD

• Subject is ≥ 12 years old.

• Subject is diagnosed with ADPKD.

⁃ Healthy volunteers

• Subject is ≥ 12 years old.

• Subject is in good general health, based on medical history and vital signs.

• Subject is matched to the patient group for age, sex and BMI.

Locations
Other Locations
Belgium
UZ Leuven
RECRUITING
Leuven
Contact Information
Primary
Flore Van Olmen, MSc
flore.vanolmen@uzleuven.be
+32 016 34 22 01
Time Frame
Start Date: 2025-09-09
Estimated Completion Date: 2026-12
Participants
Target number of participants: 150
Treatments
Patients with ADPKD
Patients with ADPKD will be included (≥ 12 years old). The somatosensory profile will be described using Quantitative Sensory Testing and questionnaires regarding pain and quality of life.
Healthy volunteers
Healthy volunteers will be included (≥ 12 years old), matched with the patient group based on age, sex and BMI. The somatosensory profile will be described using Quantitative Sensory Testing and the BPI-SF questionnaire.
Sponsors
Leads: Universitaire Ziekenhuizen KU Leuven

This content was sourced from clinicaltrials.gov