UK GCA Consortium: Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)
Status: Recruiting
Location: See all (76) locations...
Study Type: Observational
SUMMARY
A multi-centre observational study recruiting prospective and retrospective cohorts of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The primary aim is to find genetic determinants of GCA and PMR susceptibility, in order to yield novel insights into disease pathogenesis. A subset of the retrospective cohort is also enrolled in a post-marketing surveillance registry of patients eligible for, or receiving tocilizumab, to treat their relapsing or refractory GCA.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Healthy Volunteers: f
View:
• Willing to self-identify an ethnic group, such as Caucasian, Asian, Afro-Caribbean.
• Have a firm clinical diagnosis of GCA or PMR, or (for patients identified prospectively) GCA or PMR should be more likely than any alternative explanation for the patient's symptoms.
• Able and willing to give informed consent. Patients will be 50 years of age or over, unless both biopsy-proven and a clinically classical case of GCA.
Locations
Other Locations
United Kingdom
Nevill Hall Hospital, Aneurin Bevan University Health Board
RECRUITING
Abergavenny
Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust
RECRUITING
Aylesbury
Betsi Cadwaladr University Health Board
RECRUITING
Bangor
Barnsley Hospital, Barnsley Hospital NHS Foundation Trust
COMPLETED
Barnsley
Basildon University Hospital, Basildon and Thurrock University Hospitals NHS Foundation Trust
RECRUITING
Basildon
Basingstoke and North Hampshire Hospital, Hampshire Hospitals NHS Foundation Trust
RECRUITING
Basingstoke
Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust
RECRUITING
Bath
Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust
RECRUITING
Birmingham
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
RECRUITING
Birmingham
Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust
RECRUITING
Bristol
Queen's Hospital, University Hospitals of Derby and Burton NHS Foundation Trust
RECRUITING
Burton-on-trent
West Suffolk Hospital, West Suffolk NHS Foundation Trust
RECRUITING
Bury St Edmunds
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust
RECRUITING
Cambridge
Queen Elizabeth The Queen Mother Hospital
RECRUITING
Canterbury
Chelsea and Westminster Hospital, Chelsea and Westminster Hospital NHS Foundation Trust
RECRUITING
Chelsea
West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust
RECRUITING
Chelsea
Ashford and St Peter's Hospitals, Ashford & St Peter's Hospitals NHS Foundation Trust
RECRUITING
Chertsey
Countess of Chester Hospital, Countess of Chester NHS Foundation Trust
RECRUITING
Chester
Christchurch Hospital, University Hospitals Dorset NHS Foundation Trust
RECRUITING
Christchurch
Croydon University Hospital, Croydon Health Service NHS Trust
RECRUITING
Croydon
Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust
RECRUITING
Darlington
Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust
RECRUITING
Derby
Doncaster Royal Infirmary, Doncaster and Bassetlaw Hospitals NHS Foundation Trust
RECRUITING
Doncaster
Ninewells Hospital and Medical School, NHS Tayside
COMPLETED
Dundee
Royal Devon and Exeter Hospital, Royal Devon and Exeter NHS Foundation Trust
RECRUITING
Exeter
Frimley Park Hospital, Frimley Park Hospital NHS Foundation Trust
COMPLETED
Frimley
Gateshead Queen Elizabeth Hospital, Gateshead Health NHS Foundation Trust
RECRUITING
Gateshead
Inverclyde Royal Hospital, NHS Greater Glasgow and Clyde
COMPLETED
Glasgow
Royal Alexandra Hospital, NHS Greater Glasgow and Clyde
COMPLETED
Glasgow
Vale of Leven Hospital, NHS Greater Glasgow and Clyde
COMPLETED
Glasgow
James Paget Hospital, James Paget University Hospitals NHS Foundation Trust
COMPLETED
Great Yarmouth
Royal Surrey County Hospital, Royal Surrey County Hospital NHS Foundation Trust
COMPLETED
Guildford
Harrogate and District Hospital, Harrogate and District NHS Foundation Trust
RECRUITING
Harrogate
Hull Royal Infirmary, Hull and East Yorkshire NHS Trust
RECRUITING
Hull
Ipswich Hospital, East Suffolk and North Essex NHS Foundation Trust
COMPLETED
Ipswich
Airedale General Hospital, Airedale NHS Foundation Trust
RECRUITING
Keighley
Westmorland General Hospital, University Hospitals of Morecambe Bay NHS Foundation Trust
RECRUITING
Kendal
The Queen Elizabeth Hospital, The Queen Elizabeth Hospital Kings Lynn NHS Foundation Trust
COMPLETED
Kings Lynn
Royal Lancaster Infirmary, University Hospitals of Morecambe NHS Foundation Trust
RECRUITING
Lancaster
Chapel Allerton Hospital, Leeds Teaching Hospitals NHS Foundation Trust
RECRUITING
Leeds
Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust
RECRUITING
Leicester
Aintree University Hospital, Aintree University Hospitals NHS Trust
RECRUITING
Liverpool
Royal Glamorgan Hospital, Cwm Taf University Health Board
RECRUITING
Llantrisant
Hammersmith Hospital, Imperial College Healthcare NHS Trust
RECRUITING
London
King's College Hospital, King's College Hospital NHS Foundation Trust, London
RECRUITING
London
Royal Free Hospital, Royal Free NHS Foundation Trust
RECRUITING
London
St George's Hospital, St George's University Hospitals NHS Foundation Trust
RECRUITING
London
University College London Hospital, University College London NHS Foundation Trust
RECRUITING
London
Manchester Royal Infirmary, Manchester University NHS Foundation Trust
RECRUITING
Manchester
Arrowe Park Hospital, Wirral University Hospital NHS Foundation Trust
RECRUITING
Metropolitan Borough Of Wirral
Freeman Hospital, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust
RECRUITING
Newcastle
North Tyneside General Hospital, Northumbria Healthcare NHS Foundation Trust
RECRUITING
North Shields
Northampton General Hospital, Northampton General Hospital NHS Trust
RECRUITING
Northampton
Norfolk and Norwich University Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust
COMPLETED
Norwich
Queens Medical Centre, Nottingham University Hospitals NHS Trust
RECRUITING
Nottingham
Oxford Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust
NOT_YET_RECRUITING
Oxford
Peterborough City Hospital, North West Anglia NHS Foundation Trust
RECRUITING
Peterborough
Derriford Hospital, University Hospital Plymouth NHS Trust
RECRUITING
Plymouth
Poole Hospital, University Hospitals Dorset NHS Foundation Trust
RECRUITING
Poole
Whiston Hospital
RECRUITING
Prescot
Minerva Health Centre, Lancashire and South Cumbria NHS Foundation Trust
RECRUITING
Preston
Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust
RECRUITING
Preston
Salford Royal Hospital, Salford Royal NHS Foundation Trust
RECRUITING
Salford
Scarborough General Hospital, York and Scarborough Teaching Hospitals NHS Foundation Trust
RECRUITING
Scarborough
Southend University Hospital, Southend University Hospital NHS Foundation Trust
RECRUITING
Southend-on-sea
Lister Hospital, East and North Hertfordshire NHS Trust
RECRUITING
Stevenage
Haywood Hospital, Midlands Partnership NHS Foundation Trust
RECRUITING
Stoke-on-trent
Great Western Hospital, The Great Western Hospitals NHS Foundation Trust
RECRUITING
Swindon
Torbay Hospital, Torbay and South Devon NHS Foundation Trust
COMPLETED
Torquay
Royal Cornwall Hospital, Royal Cornwall Hospitals NHS Trust
RECRUITING
Truro
Pinderfields Hospital, Mid Yorkshire Hospitals NHS Trust
RECRUITING
Wakefield
Warrington Hospital, Warrington and Halton Hospitals NHS Foundation Trust
RECRUITING
Warrington
Warwick Hospital, South Warwickshire NHS Foundation Trust
COMPLETED
Warwick
Royal Hampshire County Hospital, Hampshire Hospitals NHS Foundation Trust
RECRUITING
Winchester
University Hospital Wishaw, NHS Lanarkshire
RECRUITING
Wishaw
York Hospital, York and Scarborough Teaching Hospitals NHS Foundation Trust
COMPLETED
York
Contact Information
Primary
Louise Sorensen
MRCTarget@leeds.ac.uk
0113 343 7764
Time Frame
Start Date: 2005-06-10
Estimated Completion Date: 2028-03-31
Participants
Target number of participants: 4500
Treatments
Retrospective
A patient who has a diagnosis of GCA or PMR
Prospective
Patient with suspected GCA and PMR
Related Therapeutic Areas
Sponsors
Leads: University of Leeds
Collaborators: University of Oxford