Neurofeedback for Nociplastic Pain in Rheumatoid Arthritis

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Rheumatoid arthritis is an autoimmune condition, causing inflammation and pain. Yet pain may persist even when inflammation has been treated. This residual pain, called nociplastic pain, has symptoms of a chronic pain condition called fibromyalgia. There are few effective therapies to address this residual pain. Published literature shows that fibromyalgia can be treated by neurofeedback, a noninvasive method that is based on the voluntary modulation of cortical activity. In this pilot study, the investigators want to test the effect of neurofeedback on the fibromyalgia component of pain in rheumatoid arthritis, and also to investigate its effects on related symptoms such as fatigue and sleep disturbance.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Fulfilment of the ACR/EULAR Classification Criteria for rheumatoid arthritis (RA)

• Fulfilment of the American College of Rheumatology criteria for chronic widespread pain

• Stable disease (swollen joint count ≤1 and CRP ≤10)

• Has normal or corrected to normal vision and hearing abilities

• Right-handed (to reduce baseline motor response test heterogeneity)

• Pain intensity equal or larger than 4 on the Visual Numerical Scale (0 no pain, 10, max pain imaginable)

Locations
Other Locations
United Kingdom
Clinical Research Facility (CRF), Queen Elizabeth University Hospital
RECRUITING
Glasgow
Contact Information
Primary
Aleksandra Vuckovic, PhD
aleksandra.vuckovic@glasgow.ac.uk
+44 7906441955
Time Frame
Start Date: 2024-06-24
Estimated Completion Date: 2027-01-29
Participants
Target number of participants: 16
Treatments
Experimental: Rheumatoid Arthritis - neurofeedback training
Intervention: visual neurofeedback~Research Assessments~* EEG: relaxed state and motor imagery~* Quantitative sensory testing~Questionnaires (after each intervention session):~* visual analog scale - rate pain intensity~* pain description and pain intensity reporting~* mental strategies, affects (emotional experience) and sensations during NF~* adverse event reporting~* NASA task load index~Questionnaires (week before and week after intervention weeks)~* Routine Assessment of Patient Index Data 3 (RAPID3)~* American College of Rheumatology Fibromyalgia Scale (ACRFS)~* McGill Pain Questionnaire~* Patient-Reported Outcomes Measurement Information System (PROMIS) Depression~* PROMIS-Anxiety~* PROMIS-Fatigue~* PROMIS-Sleep related impairment~* Pain Number Rating Scale~* Generalised Self-Efficiency Scale questionnaire~* Multidimensional Health Locus of Control Scale questionnaires~Remote follow-up: semi-structured interview over the telephone
Sponsors
Collaborators: University of Glasgow
Leads: NHS Greater Glasgow and Clyde

This content was sourced from clinicaltrials.gov