• Diagnosis of SjD at least 24 weeks prior to Screening Visit and meet the 2016 EULAR / ACR Classification Criteria for SjD at Screening.

• Have active moderate to severe disease (i.e., ESSDAI ≥5) at Screening.

• Laboratory parameters including the following:

‣ Absolute lymphocyte count (ALC) ≥0.5 × 10\^9/L

⁃ Peripheral CD19+ B cell count ≥25 cells/µL

⁃ Absolute neutrophil count (ANC) ≥1.0 × 10\^9/L

⁃ Hemoglobin (Hgb) ≥8 g/dL

⁃ Platelet count ≥75 × 10\^9/L

⁃ Total bilirubin ≤1.5 × ULN, except patients with confirmed Gilbert's Syndrome

⁃ Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) ≤2.0 × ULN

⁃ Estimated glomerular filtration rate (eGFR) based on the CKD-EPI formula ≥30 mL/min/1.73 m2