• Histologically and/or cytologically confirmed diagnosis of a cancer that is a locally advanced or metastatic solid tumor

• Measurable tumor lesion(s) in accordance with RECIST v1.1

• Received all standard therapy appropriate for their tumor type and stage of disease or, in the opinion of the Investigator, would be unlikely to tolerate or derive clinically meaningful benefit from appropriate standard-of-care therapy

• Resolution of any clinically relevant toxic effects of prior chemotherapy, surgery, radiotherapy, or hormonal therapy

• Presence of WT TP53 and MDM2 gene amplification by tumor tissue/blood testing, defined as ≥ 8 copies in tumor tissue by central laboratory or ≥ 8 copies or 4-fold increase in tumor tissue or blood by local testing

• Prescreening for TP53 and MDM2 at a Central Laboratory:

‣ MDM2 amplification: CN unknown and where CN cannot be derived for documentation by interpretation of reported results

⁃ MDM2 amplification: CN 6 to 7.9

⁃ MDM2 amplification: 3-3.9-fold increase

⁃ MDM2 amplification with CN ≥ 8 and with equivocal TP53 mutation upon discussion with Sponsor's Medical Monitor

• ECOG performance status of 0 or 1

• Adequate bone marrow function:

‣ Platelet count ≥ 100 × 10\^9/L

⁃ Hemoglobin ≥ 9.0 g/dL

⁃ Absolute neutrophil count ≥ 1.5 × 10\^9/L

• Adequate renal function

‣ Creatinine clearance ≥ 30mL/min, as calculated using the modified Cockcroft-Gault equation

• Adequate hepatic function

‣ Alanine aminotransferase and aspartate aminotransferase ≤ 3 × upper limit of normal (ULN) if no liver metastases are present; ≤ 5 × ULN if liver metastases are present

⁃ Total bilirubin ≤ 1.5 × ULN, or ≤ 3 x ULN in the presence of liver metastases