A Study of Hematopoietic Stem Cell Transplantation (HSCT) in Immune Function Disorders Using a Reduced Intensity Preparatory Regime
Who is this study for? Child to young adult patients with Immune Function Disorders
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 21
Healthy Volunteers: f
View:
• \</= 28 years of age
• Performance status \>/= 40
• DLCO \>/= 40%
• LVEF \>/=40% or LVSF \>/=26%
• Serum creatinine \< 2x ULN
• Liver enzymes \</= 5x ULN
• Negative pregnancy test
• Suitably matched donor (6/6 matched sib UCB, 8/8 matched sib BM or PBSC, 5-6/6 matched unrelated UCB, 7-8/8 matched unrelated BM, double cord)
Locations
United States
Missouri
Washington University
RECRUITING
St Louis
Time Frame
Start Date: 2013-03
Estimated Completion Date: 2027-03
Participants
Target number of participants: 20
Treatments
Experimental: Preparative
Related Therapeutic Areas
Sponsors
Leads: Washington University School of Medicine