Preoperative Paravertebral Block in Cancer Surgery of the Lung: ParaSOL a Prospective Randomized Controlled Clinical Trial
Who is this study for? Adults undergoing radical primary lung cancer VATS surgery for single lobectomy
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
The investigators aim to determine whether ultrasound-guided preemptive paravertebral blockade (PVB) local anaesthetic (pre-PVB LA), administered in addition to the post-operative PVB (post-PVB) local anaesthetic (LA) infusion, reduces acute postoperative pain, opioid requirement, chronic pain, and improves surgical recovery, in thoracoscopic surgery for lung cancer.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Elective radical primary lung cancer VATS surgery for single lobectomy
• American Society of Anesthesiology (ASA) I-III
• Age ≥18
Locations
Other Locations
United Kingdom
Guy's Hospital, Great Maze Pond
RECRUITING
London
Contact Information
Primary
Cheng Ong, MBBS
cheng.ong@gstt.nhs.uk
+44 2071887188
Backup
Craig R Johnstone, MBChB
craig.johnstone@gstt.nhs.uk
+44 2071887188
Time Frame
Start Date: 2019-02-01
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 100
Treatments
Placebo_comparator: Pre-PVB with saline
Placebo (20ml Saline) pre-PVB performed post-induction and pre-incision.
Experimental: Pre-PVB with 0.5% Levo-bupivacaine
20ml 0.5% Levo-bupivacaine pre-PVB performed post-induction and pre-incision.
Related Therapeutic Areas
Sponsors
Leads: Guy's and St Thomas' NHS Foundation Trust