The Impact of Splenectomy on Debridement Efficacy, Perioperative Recovery, and Prognosis in Patients With Acute Necrotizing Pancreatitis Complicated by Pancreatic Sinistral Portal Hypertension
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study is a prospective, single-center, randomized controlled trial focusing on patients with acute necrotizing pancreatitis (ANP) complicated by pancreatic sinistral portal hypertension (PSPH). The study aims to study the impact of total splenectomy on the debridement efficacy, perioperative recovery, and prognosis of patients with ANP complicated by PSPH.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Age between 18 and 75 years.
• Acute necrotic pancreatitis complicated by pancreatic sinistral portal hypertension.
• Patients undergoing open debridement for infected pancreatic necrosis
Locations
Other Locations
China
First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING
Hangzhou
Contact Information
Primary
Yun Zhang
bigzyun1977@zju.edu.cn
086-18058715288
Backup
Jian Zhang
johnzhang@zju.edu.cn
086-18758197996
Time Frame
Start Date: 2025-07-30
Estimated Completion Date: 2028-02-29
Participants
Target number of participants: 66
Treatments
Experimental: Splenectomy group
Open Debridement combined with Distal Pancreatectomy and Total Splenectomy
Experimental: Control group
Open Debridement alone
Related Therapeutic Areas
Sponsors
Leads: Zhejiang University