Evaluation of Immune Status Before and After Splenectomy in Immune Thrombocytopenia Patients
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
Evaluation of immune status before and after splenectomy in immune thrombocytopenia patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:
• Aged 18 to 60 years old, male or female;
• Conform to the diagnostic criteria of immune Thrombocytopenia (ITP)
• Needed splenectomy;
• People who are willing to sign the informed consent voluntarily and follow the research program.
Locations
Other Locations
China
Yunfei Chen
RECRUITING
Tianjin
Contact Information
Primary
Yunfei Chen, MD
chenyunfei@ihcams.ac.cn
+86-22-23909009
Backup
Lei Zhang, MD
zhanglei1@ihcams.ac.cn
+86-22-23909240
Time Frame
Start Date: 2019-01-23
Estimated Completion Date: 2025-07-23
Participants
Target number of participants: 50
Treatments
30 immune thrombocytopenia(ITP) patients
A total of 30 cases. The investigators plan to take 20ml of peripheral blood (PB) of these 30 ITP patients at 6 time points, including 1 day before surgery, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery
20 normal controls
A total of 20 cases.18 age- and gender- matched healthy donor will also be enrolled as controls and taken 20ml of peripheral blood.
Spleens of the 30 cases patients(ITP)
These 30 ITP patients agree to have splenectomy.The investigators will take a small amount of spleen tissue during surgery.
Spleens of the 10 cases patients(normal controls)
The investigators also plan to take splenic tissue from 10 patients who have splenectomy due to hereditary spherocytosis or trauma.
Related Therapeutic Areas
Sponsors
Leads: Institute of Hematology & Blood Diseases Hospital, China