Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2 Infection and Inflammation in Human Adipose Tissue
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure, Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC). This study looks at whether adipose (fat) tissue contributes to PASC by driving chronic inflammation or by serving as a reservoir for SARS-CoV-2 persistence. The results will not only determine whether obesity and IR are risk factors for PASC, but will also define fundamental biology that sets the stage for the investigation of novel or existing therapies that target the causal pathways identified.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:
• Ages 18 to 80
• BMI ≥ 25 kg/m2
• not currently pregnant
Locations
United States
California
Clinical and Translational Research Unit
ENROLLING_BY_INVITATION
Palo Alto
Stanford Health
RECRUITING
Palo Alto
Contact Information
Primary
Nicole Turk, BS
nturk@stanford.edu
6508880144
Time Frame
Start Date: 2023-06-06
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 55
Treatments
No_intervention: Chart Review (not actively recruiting)
Chart review of previously consented participants from the entire NIH RECOVER cohort, comprised of 15,000 infected and 2,600 noninfected patients across the country.
Experimental: COVID infected and healthy controls
Participants will perform a needle fat biopsy for tissue harvesting in the subacute phase (15-30d) of Covid-19 infection or as a healthy control. Our goal is 20 COVID-19 infected participants and 10 healthy controls.
Experimental: Healthy Controls Only
We are looking for 20 healthy controls for 2 in-person visits on separate days.~1. An Insulin Sensitivity Test (SSPG: Steady State Plasma Glucose) is performed to determine if the participant is insulin-sensitive or insulin resistant.~2. A Needle Fat Biopsy: After an overnight fast, approximately 1-2 grams of subcutaneous fat will be removed by a needle. Patients will have a local anesthetic prior to the procedure.
Related Therapeutic Areas
Sponsors
Leads: Stanford University