Music and Cognitive Deficits in Self-Limited Epilepsy with Centrotemporal Spikes

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Self-limited epilepsy with centrotemporal spikes (SeLECTS) is the most frequent epilepsy syndrome in children between the ages of 4 and 13 years. SeLECTS is associated in 15 to 30% of patients with specific cognitive deficits, including in particular disorders in language, visuo-spatial memory, declarative memory, and attention. SeLECTS has the potential to evolve into Landau-Kleffner syndrome, the most extreme form of SeLECTS including symptoms of auditory agnosia and aphasia, with potential risks of persistent neuropsychological impairments. In a recent study in adults who had suffered Landau-Kleffner syndrome during childhood, the investigators have shown that these patients, in addition to their known deficit in verbal short-term memory, also exhibit persistent musical difficulties during adulthood, with in particular deficit in melody and rhythm short-term memory. In the present project, the investigators intend to enlarge the understanding of cognitive deficits generated by SeLECTS in children by investigating the integrity of music perception, both for melody and rhythm. To date, data about music perception in children with epilepsy are scarce and we do not know how distinct components of melody and rhythm perception and memory may be altered.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 5
Maximum Age: 14
Healthy Volunteers: f
View:

• Subject aged between 5 and 14 years old

• Non-opposition of parents or guardians for the child's participation in the study

• No major cognitive impairment and ability to understand and apply instructions

• Subject affiliated to a social security scheme

• Subject motivated to participate in the project

• Proficiency with the French language

⁃ For the group of control participants:

⁃ • Without neurological or psychiatric history

⁃ For the group of participants with seizure disorder:

• No neurological (except EPCT) or psychiatric history

• Diagnosis of self-limited epilepsy with centro-temporal spikes (PTSE) by a qualified healthcare professional.

Locations
Other Locations
France
Centre Hospitalier Le Vinatier (Bât. 452),
NOT_YET_RECRUITING
Bron
Hospices Civils de Lyon
RECRUITING
Bron
Contact Information
Primary
Maria PAPADOPOULOU, MD
maria.papadopoulou@chu-lyon.fr
04 27 85 65 78
Backup
Anne CACLIN, PhD
anne.caclin@inserm.fr
04.72.13.89.04
Time Frame
Start Date: 2024-11-13
Estimated Completion Date: 2026-11
Participants
Target number of participants: 100
Treatments
Patients
This group consists of children and adolescents between the ages of 5 and 14, diagnosed with self-limited epilepsy with centrotemporal spikes by a medical professional (epileptologist or neurologist), and in the active phase of the disorder.
Controls
This group consists of healthy individuals between 5 and 14 years old, with no history of epilepsy and/or other neurodevelopmental disorders.
Sponsors
Leads: Hospices Civils de Lyon

This content was sourced from clinicaltrials.gov