The Role of Neurofilament Light (NfL) in Management of Patients With Hydrocephalus: A Pilot Study

Status: Completed

Intervention Type: Procedure, Diagnostic test

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

Neurofilament Light Chain Protein (NfL) has been found by many studies as a sensitive biomarker of neuronal damage from several reasons, e.g. neurodegenerative diseases (Alzheimer's disease, Multiple Sclerosis, etc.), inflamation (HIV) or trauma. Its role as biomarker thus offers a possibility to predict and manage diseases associated with neuronal damage. Therefore our aim is to investigate the changes in level of NfL in hydrocephalus and to find its role in management of treatment in hydrocephalus.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 50

Healthy Volunteers: f

View:

• In group A:

‣ Patients with diagnosed communicating hydrocephalus

⁃ MMSE \> 10 points

⁃ Absence of any structural laesion on MRI or CT

⁃ Accepted Informed consent

• In group B:

‣ MMSE \> 10 points

⁃ Absence of any structural laesion on MRI or CT

⁃ Accepted Informed consent

⁃ Elective spinal surgery without affecting dural sac and the spinal cord

⁃ Surgery shorter than 120 minutes of lasting the general anesthesia

Time Frame

Start Date: 2023-12-07

Completion Date: 2025-09-27

Participants

Target number of participants: 41

Treatments

Experimental: Study group A

Patients with diagnosed hydrocephalus undergoing surgery (VP shunt placement) in general anestezia. Before surgery patients undergo lumbar puncture or external lumbar drainage placement to confirmate the diagnosis and responsivity to VP shunt placement.

Active_comparator: Study group B

Patients without diagnosed hydrocephalus undergoing short spinal surgery without affecting dural sac (e.g. anterior cervical discectomy and fusion or lumbar disc herniation or lumbar decompression) in general anestezia.

Related Therapeutic Areas

Multiple Sclerosis (MS)

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