Feasibility of a Multifaceted Intervention to Mitigate the Cardiovascular Adverse Effects of Air Pollution: The COATED-AIR Feasibility Trial
The main goal of this clinical trial is to evaluate the feasibility of conducting a large-scale clinical trial testing a program containing several aspects for reducing the effects of air pollution on cardiovascular health (which is named the hybrid program hereafter) in adult patients (18 years or older) with atherosclerotic cardiovascular disease. Furthermore, we seek to answer how much patients adhere to and are satisfied with implementing the hybrid program, and what problems executing this program will bring for patients.
• Adult patients (≥18 years) with documented ASCVD defined as at least one of the following:
‣ Coronary artery disease (CAD):
• Previous or recent documented type I myocardial infarction
∙ History of coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery)
∙ History of obstructive CAD (\>50% stenosis) documented by coronary computed tomography (CT) or conventional angiography
⁃ Peripheral arterial disease (PAD):
• Previous or recent acute ischemic limb event (\>7 days prior)
∙ History of previous endovascular/surgical lower or upper extremities revascularization for an atherosclerotic cause
∙ History of ulcer or lower extremities amputation due to ASCVD.
⁃ Carotid arterial diseases:
• History of previous endovascular/surgical carotid artery revascularization for atherosclerotic cause
∙ History of \> 50% carotid artery stenosis based on documented imaging tests (Duplex ultrasonography, CT angiography, magnetic resonance angiography, or conventional angiography)
⁃ Ischemic stroke:
• History of recent or previous documented ischemic stroke not due to systemic hypoperfusion/hypotension being treated with low-dose aspirin
• Willing to participate and able to provide written informed consent