Biologic Association Between Metabolic MR-PET and Tissue Measures of Glycolysis in Brain Tumors Visualization, Quantitation, and Targeting of Infiltrating Glioblastoma Cells With pH Sensitive Amine Chemical Exchange Saturation Transfer Magnetic Resonance Imaging-KL2TR001882
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY
The purpose of this project is to validate a new combined MRI and PET imaging technique as a biomarker or measure of glycolysis in brain tumors. To accomplish this, the investigators propose obtaining image-guided measures of tissue pH and biopsied tissue in tumor areas selected for bulk resection surgery. Investigators will then correlate the imaging measurements with pH, RNA expression, protein expression, and bioenergetics measurements of key glycolytic enzymes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age \> 18
• Patients with newly diagnosed or recurrent glioblastoma clinically indicated for resective surgery
Locations
United States
California
University of California at Los Angeles
RECRUITING
Los Angeles
Contact Information
Primary
Raksha Nagaraj
RNagaraj@mednet.ucla.edu
310-794-8995
Backup
Saima Chaabane
schaabane@mednet.ucla.edu
310-794-8995
Time Frame
Start Date: 2023-09-06
Estimated Completion Date: 2028-09-30
Participants
Target number of participants: 50
Treatments
Other: Arm I en vivo Glycolic Index measurement
All biopsies are acquired for standard of care and according to standard of care procedures. A 13-gauge biopsy needle and plastic cannula will be inserted into the region of interest identified on MRI and PET. The biopsy needle will be removed, and the Softcell® pH probe, consisting of a 1.8mm diameter high quality glass tip and 1.6m long wire, will be guided down the cannula and inserted at least 15mm into the tissue. Recordings will be made for 1 minute to stabilize the reading, then the pH probe will be removed from the region of interest and placed into a saline vial for the next biopsy target.
Related Therapeutic Areas
Sponsors
Collaborators: Nitional institute of Health -National Center for Advancing Translational Sciences
Leads: Jonsson Comprehensive Cancer Center