Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas
Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory, and other cognitive functions. These cognitive deficits frequently have significant impact on patient quality of life. Although currently, there is no established standard of care to treat cognitive deficits in brain tumor patients, standard cognitive rehabilitative treatments have been developed for those with traumatic brain injury and stroke. However, the feasibility and efficacy of these cognitive treatments in individuals with brain tumors remains unclear.
• Histologically confirmed low grade supratentorial primary brain tumor
• \>= 18 years old
• Life expectancy \> 12 weeks
• Karnofsky performance status (KPS) \>= 70
• Must speak and be able to read English fluently
• Must have access to the internet
• Must have text enabled cellphone
• Must be receiving MRI scans at University of California, San Francisco (UCSF)
• Must be clinically stable and off treatment (e.g. radiation or chemotherapy) for ≥ 3 months
• Must be \>= 6 months from craniotomy
• Must have subjective complaints of cognitive deficits
• Must have adequate seizure control and be on a stable, or decreasing, dose of anti-epileptics
• Must score \<= 1 SD below normal on ≥ 2 or more domains of baseline neuropsychological assessments
• Have a presumed low grade primary brain tumor and either be undergoing definitive surgery at UCSF or have had surgical resection at UCSF within the last 3 months.
• Prior surgery is allowed if they are coming to UCSF for definitive surgery and have not received additional systemic treatment or radiation.
• \>= 18 years old
• Must speak and be able to read English fluently.
• Plan to continue to care in neuro-oncology at UCSF
• Must be receiving MRI scans.