Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant Bronchopulmonary Dysplasia (BPD, Also Known as Chronic Lung Disease of Prematurity) Through Exercise (FLASHLITE)
This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic lung disease (CLD) of prematurity, and post-heart transplant (HT))
• Cases:
‣ Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
⁃ 8-25 years old
⁃ Height: ≥ 48 inches
⁃ Ambulatory without assistance
⁃ English speaking
⁃ Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
⁃ SpO2 \>92%
⁃ Not pregnant
⁃ ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
• Controls
‣ 8-25 years old
⁃ Height: ≥ 48 inches
⁃ Ambulatory without assistance
⁃ English speaking
⁃ No history of arrhythmia or known cardiac dysfunction at baseline
⁃ Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
⁃ SpO2 \>95%
⁃ Not pregnant