Overview
Nicholas Maragakis treats patients with motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). This care is coordinated with the Johns Hopkins Center for ALS Specialty Care, a multidisciplinary clinic with expertise in treating patients with ALS and providing support to their caregivers. He serves as medical director of the ALS Clinical Trials Unit, an extension of the multidisciplinary clinic that seeks to facilitate opportunities for patients with ALS to participate in clinical trials that could advance the treatment of this disease. Dr. Maragakis is interested in the basic science of understanding neurodegenerative diseases, as well as the translational potential of therapeutic compounds developed in the laboratory. His fundamental research interest is in using stem cells — more specifically, stem cell-derived motor neurons and glia — for understanding the development and propagation of ALS. His laboratory has been involved in creating and characterizing lines of stem cells from patients with ALS using induced pluripotent stem cell (iPSC) methodologies. The laboratory has a large library of iPSCs from patients with familial ALS and from patients with sporadic ALS. The utilization of this library of iPSCs has facilitated the development of a spinal cord-specific iPSC-astrocyte/motor neuron co-culture system, which has been leveraged for the development of assays that can be used for both the basic understanding of ALS astrocyte and motor neuron biology as well as, eventually, drug screening for ALS therapeutics. His laboratory has taken its long-standing interests in astrocyte biology, as it relates to ALS, to develop a program that investigates astrocyte-specific mechanisms as contributors to the progression (both temporally and anatomically) of disease in ALS. In this vein, there is an interest in astrocytic glutamate transporters and, more recently, astrocyte hemichannels and gap junctions.
Dr. Maragakis is rated as a Distinguished provider by MediFind in the treatment of Dysarthria. His top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Primary Lateral Sclerosis, 15q11.2 Microdeletion, and Spinal Muscular Atrophy (SMA).
His clinical research consists of co-authoring 115 peer reviewed articles and participating in 3 clinical trials. MediFind looks at clinical research from the past 15 years. In particular, he has co-authored 2 articles in the study of Dysarthria.
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Locations
601 North Caroline Street, Floor 5, Floor 5, Baltimore, MD 21287
Clinical Research
Clinical research consists of overseeing clinical studies of patients undergoing new treatments and therapies, and publishing articles in peer reviewed medical journals. Providers who actively participate in clinical research are generally at the forefront of the fields and aware of the most up-to-date advances in treatments for their patients.
3 Clinical Trials
Johns Hopkins Outpatient Center
Dr. Jeffrey Rothstein focuses on neuromuscular diseases, with a particular focus on Amyotrophic lateral sclerosis (ALS). Other clinical areas relevant to his laboratory-based research include idiopathic stupor, epilepsy, and motor neuron degeneration. His laboratory includes more than 25 post-doctoral fellows, neurology residents, neuromuscular fellows, junior faculty, undergraduate students, technicians, and ALS clinic staff. He has been the principal and/or local investigator in more than 20 national or international trials in ALS. He is the author of more than 360 articles on basic and clinical neuroscience. Dr. Rothstein's laboratory research is funded through the National Institutes of Health, the Dept of Defense, Target ALS, Maryland TEDCO, Alzheimer's Drug Discovery Foundation, the Muscular Dystrophy Association, the ALS Association, and Answer ALS. Dr. Jeffrey Rothstein received a masters degree in neurochemistry from the University of Chicago and a Ph.D. in physiology and biophysics from the University of Illinois Health Sciences Center. He then obtained his medical degree from the University of Illinois College of Medicine. He went on to complete an internship at the University of North Carolina Memorial Hospital before joining The Johns Hopkins for his residency. While at Johns Hopkins, he became chief resident in neurology and completed his fellowship in neuromuscular disease. He has been Professor of Neurology and Neuroscience at Johns Hopkins for more than 25 years. Dr. Rothstein is rated as an Advanced provider by MediFind in the treatment of Dysarthria. His top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Spinal Muscular Atrophy (SMA), Spinal and Bulbar Muscular Atrophy, and Spinal Muscular Atrophy Type 3.
Comprehensive Neurology Services, PA
Sean Burke is a Neurologist and a Neuromusculoskeletal Medicine provider in Frederick, Maryland. Dr. Burke is rated as an Advanced provider by MediFind in the treatment of Dysarthria. His top areas of expertise are Seizures, Multiple Sclerosis (MS), Relapsing Multiple Sclerosis (RMS), and Peripheral Neuropathy. Dr. Burke is currently accepting new patients.
Areas of Expertise
MediFind evaluates expertise by pulling from factors such as number of articles a doctor has published in medical journals, participation in clinical trials, speaking at industry conferences, prescribing and referral patterns, and strength of connections with other experts in their field.
Learn more about MediFind’s expert tiers
- Elite
- 15q11.2 MicrodeletionDr. Maragakis isElite. Learn about 15q11.2 Microdeletion.
- Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease)
- Primary Lateral SclerosisDr. Maragakis isElite. Learn about Primary Lateral Sclerosis.
- Distinguished
- DysarthriaDr. Maragakis isDistinguished. Learn about Dysarthria.
- Spinal and Bulbar Muscular AtrophyDr. Maragakis isDistinguished. Learn about Spinal and Bulbar Muscular Atrophy.
- Spinal Muscular Atrophy (SMA)Dr. Maragakis isDistinguished. Learn about Spinal Muscular Atrophy (SMA).
- Spinal Muscular Atrophy Type 3Dr. Maragakis isDistinguished. Learn about Spinal Muscular Atrophy Type 3.
- Experienced
- Alternating Hemiplegia of ChildhoodDr. Maragakis isExperienced. Learn about Alternating Hemiplegia of Childhood.
- Chronic PolyradiculoneuritisDr. Maragakis isExperienced. Learn about Chronic Polyradiculoneuritis.
- Cramp-Fasciculation SyndromeDr. Maragakis isExperienced. Learn about Cramp-Fasciculation Syndrome.
- Creutzfeldt-Jakob DiseaseDr. Maragakis isExperienced. Learn about Creutzfeldt-Jakob Disease.
- DementiaDr. Maragakis isExperienced. Learn about Dementia.
- Dry MouthDr. Maragakis isExperienced. Learn about Dry Mouth.