Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
The study aims to investigate the prognostic significance of olfactory function in patients with glioblastoma. We are examining olfactory function at various points during therapy and correlating the results with survival data. In addition, neurocognitive tests will be carried out to correlate the results of olfactory function with the patient's cognitive abilities. Investigations into the quality of life and psychological condition of the patients are also performed. In addition to the cohort of glioblastoma patients, there is a control cohort without tumor disease in which the olfactory testing is also carried out in order to have a comparison.
• At least 18 years of age
• Newly-diagnosed glioblastoma (IDH wild-type)
• Never received prior chemotherapy
• Never received radiotherapy to the head or neck before
• KPS ≥ 70
• No history of severe head or brain trauma requiring ICU admission or classified as Glasgow Coma Scale grade 3
• No respiratory infection at the time of inclusion
• No significant aphasia