Dr. Ana M. Franceschi

Professionally, I am highly motivated and dedicated to making significant contributions to advancing Neuroradiology research and practice. Specifically, I have developed a special focus on neurological molecular imaging, with an emphasis on the advancement of brain PET/MRI and hybrid imaging techniques in dementia and neurodegenerative disease. I was awarded the Foundation of the ASNR 2021 Boerger Research Fund for Alzheimer s Disease and Neurocognitive Disorders for the project [18F] PI-2620 in Primary Progressive Aphasia (Franceschi AM, PI), with the goal of characterizing biodistribution of abnormal tau accumulation in PPA subtypes using the novel second generation tracer PI-2620 and correlating these findings with clinical disease severity and neurodegeneration. I am also PI for the project Utility of [18F] PI-2620 as Universal Biomarker for the A/T/N Classification of Dementia and Neurodegenerative Disease , which aims to establish the efficacy of PI-2620 as a single, universal biomarker for the A/T/N classification scheme of dementia, with the eventual goal of its use in descriptive classification, patient selection and target engagement assessment in disease-modifying clinical treatment trials. I contribute as a co-Investigator on the study A Life Course Approach to Integrating Trauma and Cognitive Aging: A Cohort of 9/11 Responders, which is part of the World Trade Center (WTC) responders aging program (NIH R01 AG049953; Clouston, PI). This research focuses on PTSD and WTC exposures as risk factors for cognitive dysfunction and decline in a prospective cohort of responders, alongside changes in -amyloid, tau deposition, and neurodegeneration. These varied experiences have allowed me to understand the characterization of non-Alzheimer s tauopathies, and have improved my analytical expertise to apply this knowledge to studying Alzheimer s disease and related neurocognitive disorders. In addition to multiple scientific publications on these topics, I am lead editor of the textbook Hybrid PET/MR Neuroimaging: A Comprehensive Approach (Springer Nature, 2022).

Dr. Franceschi is rated as an Advanced provider by MediFind in the treatment of Hydrocephalus. Her top areas of expertise are Hydrocephalus, Meningioma, Stroke, Normal Pressure Hydrocephalus, and Thrombectomy.

Her clinical research consists of co-authoring 59 peer reviewed articles. MediFind looks at clinical research from the past 15 years. In particular, she has co-authored 3 articles in the study of Hydrocephalus.